382180-17-8
N-hydroxy-N'-(pyridin-3-yl)octanediamide
CAS: 382180-17-8
Molecular Formula: C13H19N3O3
382180-17-8 - Names and Identifiers
| Name | N-hydroxy-N'-(pyridin-3-yl)octanediamide |
| Synonyms | NSC 696085 NSC696085 Pyroxamide NSC-696085 382180-17-8 NSC 696085 PyroxaMide (NSC 696085) N-Hydroxy-N'-3-pyridinyloctanediamide N-HYDROXY-N'-3-PYRIDINYLOCTANEDIAMIDE N1-Hydroxy-N8-3-pyridinyl-octanediamide N-hydroxy-N'-(pyridin-3-yl)octanediamide n-hydroxy-n'-(pyridin-3-yl)octanediamide N-HYDROXY-N'-(PYRIDIN-3-YL)OCTANEDIAMIDE N1-Hydroxy-N8-(pyridin-3-yl)octanediamide 2-[1-carbaMoyl-N-(2H-pyran-2-yl)forMaMido]-N-hydroxy-N'-(pyridin-3-yl)octanediaMide |
| CAS | 382180-17-8 |
| InChI | InChI=1/C13H19N3O3/c17-12(15-11-6-5-9-14-10-11)7-3-1-2-4-8-13(18)16-19/h5-6,9-10,19H,1-4,7-8H2,(H,15,17)(H,16,18) |
382180-17-8 - Physico-chemical Properties
| Molecular Formula | C13H19N3O3 |
| Molar Mass | 265.31 |
| Density | 1.215g/cm3 |
| Solubility | DMSO: soluble10mg/mL (clear solution) |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | -20°C |
| Refractive Index | 1.569 |
| In vitro study | Pyroxamide (1.25-20.0 μM; 24-72 hours) suppresses RD and RH30B cells growth, pyroxamide resulted in 44% dead cells for 72 h at 20.0 μM, results in 86% dead cells in culture. Pyroxamide (10.0-20.0 μM; 48 hours) shows sub-G1fractions of 45.0% and 72.3% at 10.0 and 20.0 μM, respectively. Cell Viability Assay Cell Line: RD cells; RH30B cells Concentration: 1.25-20.0 μM Incubation Time: 24 hours; 48 hours; 72 hours Result: Resulted in a cell growth decrease in RD and RH30B cells. Cell Cycle Analysis Cell Line: RD cells; RH30B cells Concentration: 10.0 μM; 20.0 μM Incubation Time: 48 hours Result: Increased the sub-G1fractions at 48 hours compared with control samples. |
382180-17-8 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
382180-17-8 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.769 ml | 18.846 ml | 37.692 ml |
| 5 mM | 0.754 ml | 3.769 ml | 7.538 ml |
| 10 mM | 0.377 ml | 1.885 ml | 3.769 ml |
| 5 mM | 0.075 ml | 0.377 ml | 0.754 ml |
Last Update：2024-01-02 23:10:35
382180-17-8 - Reference Information
| biological activity | Pyroxamide is an effective histone deacetylase 1 (HDAC1) inhibitor with ID50 of 100 nM. Pyroxamide can induce leukemia cell apoptosis and cell cycle arrest. |
| target | ID50: 100 nM |
| in vitro study | Pyroxamide (1.25-20.0 μM; 24-72 hours) suppresses RD and RH30B cells growth, pyroxamide resulted in 44% dead cells for 72 h at 20.0 μM, results in 86% dead cells in culture. Pyroxamide (10.0-20.0 μM; 48 hours) shows sub-G1fractions of 45.0% and 72.3% at 10.0 and 20.0 μM, respectively. Cell Viability Assay Cell Line: RD cells; RH30B cells Concentration: 1.25-20.0 μM Incubation Time: 24 hours; 48 hours; 72 hours Result: Resulted in a cell growth decrease in RD and RH30B cells. Cell Cycle Analysis Cell Line: RD cells; RH30B cells Concentration: 10.0 μM; 20.0 μM Incubation Time: 48 hours Result: Increased the sub-G1fractions at 48 hours compared with control samples. |
| Cell Line: | RD cells; RH30B cells RD cells; RH30B cells |
| Concentration: | 1.25-20.0 μM 10.0 μM; 20.0 μM |
| Incubation Time: | 24 hours; 48 hours; 72 hours 48 hours |
| Result: | Resulted in a cell growth decrease in RD and RH30B cells. Increased the sub-G1fractions at 48 hours compared with control samples. |
Last Update：2024-04-09 02:00:02
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