4-(Boc-Aminomethyl)piperidine
4-(Boc-Aminomethyl)piperidine
CAS: 135632-53-0
Molecular Formula: C11H22N2O2
4-(Boc-Aminomethyl)piperidine - Names and Identifiers
4-(Boc-Aminomethyl)piperidine - Physico-chemical Properties
| Molecular Formula | C11H22N2O2 |
| Molar Mass | 214.3 |
| Density | 0.981±0.06 g/cm3(Predicted) |
| Melting Point | 106 °C |
| Boling Point | 321.8±15.0 °C(Predicted) |
| Flash Point | 148.4°C |
| Solubility | Soluble in DMSO. |
| Vapor Presure | 0.00029mmHg at 25°C |
| Appearance | White solid |
| pKa | 12.72±0.46(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| MDL | MFCD01631214 |
4-(Boc-Aminomethyl)piperidine - Risk and Safety
| Risk Codes | R34 - Causes burns R36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3259 |
| HS Code | 29333990 |
| Hazard Note | Corrosive |
| Hazard Class | IRRITANT |
| Packing Group | Ⅲ |
4-(Boc-Aminomethyl)piperidine - Introduction
4-Boc-aminomethylpiperidine (-) is an organic compound. Its properties are as follows:
1. Appearance: 4-Boc-aminomethylpiperidine is a white crystalline solid.
2. Chemical structure: Its chemical structure contains an N-methyl piperidine ring and a Boc(tert-butoxycarbonyl) protecting group.
3. Solubility: 4-Boc-aminomethylpiperidine has good solubility in common organic solvents.
4-Boc-aminomethylpiperidine has a wide range of uses in organic synthesis, commonly used in the following aspects:
1. As an intermediate: It can be used as an intermediate for the synthesis of drugs, dyes and other organic compounds. For example, it is possible to introduce an amino function by removing the Boc protecting group.
2. Acylation reaction: 4-Boc-aminomethylpiperidine can be used for acylation reaction, and the anhydride reacts with it to generate acylated product.
A common method for preparing 4-Boc-aminomethylpiperidine is by N-methylation of piperidine and using Boc acid to protect the hydroxyl group. Specific steps are as follows:
1. Reaction: The piperidine is reacted with a methylating agent (such as methyl sodium iodide) to obtain N-methyl piperidine.
2. Protection: 4-Boc-aminomethylpiperidine is obtained by reacting N-methylpiperidine with Boc acid.
The following safety information should be noted when handling 4-Boc-aminomethylpiperidine:
1. toxicity: 4-Boc-aminomethylpiperidine may produce certain toxicity to the human body, so protective gloves and respirators should be worn during operation.
2. Avoiding light preservation: 4-Boc-aminomethylpiperidine should be sealed and stored in a cool, dark place to prevent its degradation by light.
3. fire: it is a flammable substance, should avoid contact with the fire source.
4. Waste disposal: Waste should be disposed according to local regulations and should not be dumped at will.
1. Appearance: 4-Boc-aminomethylpiperidine is a white crystalline solid.
2. Chemical structure: Its chemical structure contains an N-methyl piperidine ring and a Boc(tert-butoxycarbonyl) protecting group.
3. Solubility: 4-Boc-aminomethylpiperidine has good solubility in common organic solvents.
4-Boc-aminomethylpiperidine has a wide range of uses in organic synthesis, commonly used in the following aspects:
1. As an intermediate: It can be used as an intermediate for the synthesis of drugs, dyes and other organic compounds. For example, it is possible to introduce an amino function by removing the Boc protecting group.
2. Acylation reaction: 4-Boc-aminomethylpiperidine can be used for acylation reaction, and the anhydride reacts with it to generate acylated product.
A common method for preparing 4-Boc-aminomethylpiperidine is by N-methylation of piperidine and using Boc acid to protect the hydroxyl group. Specific steps are as follows:
1. Reaction: The piperidine is reacted with a methylating agent (such as methyl sodium iodide) to obtain N-methyl piperidine.
2. Protection: 4-Boc-aminomethylpiperidine is obtained by reacting N-methylpiperidine with Boc acid.
The following safety information should be noted when handling 4-Boc-aminomethylpiperidine:
1. toxicity: 4-Boc-aminomethylpiperidine may produce certain toxicity to the human body, so protective gloves and respirators should be worn during operation.
2. Avoiding light preservation: 4-Boc-aminomethylpiperidine should be sealed and stored in a cool, dark place to prevent its degradation by light.
3. fire: it is a flammable substance, should avoid contact with the fire source.
4. Waste disposal: Waste should be disposed according to local regulations and should not be dumped at will.
Last Update：2024-04-09 20:49:11
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