4-(trifluoromethyl)pyridine
4-(trifluoromethyl)pyridine
CAS: 3796-24-5
Molecular Formula: C6H4F3N
4-(trifluoromethyl)pyridine - Names and Identifiers
| Name | 4-(trifluoromethyl)pyridine |
| Synonyms | à,à,à-trifluoro-4-picoline 4-(TRIFLUOROMETHYL)PYRIDINE 4-(trifluoromethyl)pyridine Pyridine, 4-(trifluoromethyl)- alpha,alpha,alpha-Trifluoro-4-picoline |
| CAS | 3796-24-5 |
| EINECS | 626-602-9 |
| InChI | InChI=1/C10H13FN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2 |
4-(trifluoromethyl)pyridine - Physico-chemical Properties
| Molecular Formula | C6H4F3N |
| Molar Mass | 147.1 |
| Density | 1.27 g/mL at 25 °C (lit.) |
| Boling Point | 110 °C (lit.) |
| Flash Point | 68°F |
| Vapor Presure | 0.00104mmHg at 25°C |
| BRN | 1364589 |
| pKa | 2.92±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | n20/D 1.417(lit.) |
4-(trifluoromethyl)pyridine - Risk and Safety
| Risk Codes | R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/60 - |
| UN IDs | UN 1993 3/PG 2 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Note | Irritant/Flammable |
| Hazard Class | 3 |
| Packing Group | II |
4-(trifluoromethyl)pyridine - Introduction
4-(trifluoromethyl)pyridine is an organic compound with the chemical formula C7H4F3N. It is a colorless liquid with a pungent odor.
The 4-(trifluoromethyl)pyridine has many applications. First, it can be used as an important reagent in organic synthesis. It is often used in catalysts, catalytic reactions, dehydrogenation agents in chemical reactions, etc. Secondly, 4-(trifluoromethyl)pyridine can also be used as pharmaceutical intermediates for the synthesis of some drugs. In addition, it can also be used as a fluorescent probe and labeling reagent in the research field.
There are various methods for preparing 4-(trifluoromethyl)pyridine. One common method is synthesis by dearomatizing trifluorotoluene and pyridine. The specific steps include performing negative solvent replacement on trifluorotoluene, then performing a heating dearomatizing reaction with pyridine, and finally purifying the product by distillation.
When using 4-(trifluoromethyl)pyridine, you need to pay attention to its safety information. It is flammable and should avoid direct contact with fire. During the operation, avoid inhaling its vapor or touching the skin and eyes. Use should wear appropriate protective equipment, such as chemical protective gloves, glasses and protective masks. When stored, it should be kept in a sealed container, away from fire and oxidizing agents. In case of leakage, appropriate measures shall be taken immediately to clean up.
The 4-(trifluoromethyl)pyridine has many applications. First, it can be used as an important reagent in organic synthesis. It is often used in catalysts, catalytic reactions, dehydrogenation agents in chemical reactions, etc. Secondly, 4-(trifluoromethyl)pyridine can also be used as pharmaceutical intermediates for the synthesis of some drugs. In addition, it can also be used as a fluorescent probe and labeling reagent in the research field.
There are various methods for preparing 4-(trifluoromethyl)pyridine. One common method is synthesis by dearomatizing trifluorotoluene and pyridine. The specific steps include performing negative solvent replacement on trifluorotoluene, then performing a heating dearomatizing reaction with pyridine, and finally purifying the product by distillation.
When using 4-(trifluoromethyl)pyridine, you need to pay attention to its safety information. It is flammable and should avoid direct contact with fire. During the operation, avoid inhaling its vapor or touching the skin and eyes. Use should wear appropriate protective equipment, such as chemical protective gloves, glasses and protective masks. When stored, it should be kept in a sealed container, away from fire and oxidizing agents. In case of leakage, appropriate measures shall be taken immediately to clean up.
Last Update：2024-04-09 21:01:54
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