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4-Methylanisole

4-Methylanisole

CAS: 104-93-8

Molecular Formula: C8H10O

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4-Methylanisole - Names and Identifiers

Name 4-Methylanisole
Synonyms MSO
Mso
FEMA 2681
Fema 2681
4-Methylanisole
P-Methylanisole
METHYL-P-CRESOL
Methyl-P-Cresol
4-METHYLANISOLE
4-Methoxytoluene
4-METHOXYTOLUENE
METHYL P-TOLYL ETHER
Methyl P-Tolyl Ether
P-CRESYL METHYL ETHER
P-Cresyl Methyl Ether
1-METHOXY-4-METHYLBENZENE
1-Methoxy-4-Methylbenzene
CAS 104-93-8
EINECS 203-253-7
InChI InChI=1/C8H10O/c1-6-3-4-8(9)7(2)5-6/h3-5,9H,1-2H3

4-Methylanisole - Physico-chemical Properties

Molecular FormulaC8H10O
Molar Mass122.16
Density0.969g/mLat 25°C(lit.)
Melting Point-32°C
Boling Point174°C(lit.)
Flash Point128°F
JECFA Number1243
Water Solubilityslightly soluble
Vapor Presure5.25 mm Hg ( 50 °C)
AppearanceLiquid
ColorClear colorless to slightly yellow
Maximum wavelength(λmax)['279nm(MeOH)(lit.)']
BRN1237336
Storage ConditionSealed in dry,Room Temperature
StabilityStable. Incompatible with strong oxidizing agents. Combustible.
Explosive Limit1.1-8.3%(V)
Refractive Indexn20/D 1.511(lit.)
Physical and Chemical PropertiesDensity 0.96
boiling point 174°C
refractive index 1.51-1.513
flash point 53°C
water-soluble clear solution
UseFor the preparation of walnut, hazelnut and other nut-type spices

4-Methylanisole - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR22 - Harmful if swallowed
R38 - Irritating to the skin
R10 - Flammable
R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
R63 - Possible risk of harm to the unborn child
Safety DescriptionS36/37 - Wear suitable protective clothing and gloves.
S16 - Keep away from sources of ignition.
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. 
UN IDsUN 1993 3/PG 3
WGK Germany1
RTECSBZ8780000
TSCAYes
HS Code29093090
Hazard Class3
Packing GroupIII
ToxicityThe acute oral LD50 in rats was reported as 1.92 (1.51-2.45) g/kg (Hart, 1971). The acute dermal LD50 in rabbits was reported as > 5 g/kg (Hart, 1971).

4-Methylanisole - Reference Information

FEMA2681 | P-METHYLANISOLE
olfactory Threshold 0.0012ppm
LogP2.74-2.8 at 25-35℃
NIST chemical information information provided by: webbook.nist.gov (external link)
EPA chemical substance information information provided by: ofmpeb.epa.gov (external link)
content analysis measured by gas chromatography (GT-10-4) using a polar column method.
toxicity GRAS(FEMA). LD50 1920mg/kg (rat, oral).
usage limit FEMA(mg/kg): soft drinks 2.7; Cold drinks 2.7; Candy 4.8; Baked goods 7.6; pudding 0.50~4.0; Condiment 2.0; Syrup 8.0. Moderate limits (FDA § 172.515,2000).
Use can be used for large flower jasmine, white blue, ylang ylang, narcissus, yellow lotus, balloon, Hyacinth, in the fragrant type of the Golden passerine. Can also be used for trace Lily, Rose, clove type. Can be used with brominated styrene in soap flavor, occasionally used in food flavor, mainly for nut flavor type, such as walnut, hazelnut flavor.
GB 2760-96 provides for the permitted use of flavorants. Mainly used for the preparation of walnut, hazelnut and other nut-type flavor.
This product has the fragrance of violet and fragrance and the fragrance of ylang ylang. It is naturally found in ylang ylang oil and carnanga ylang oil, and is one of the more important ethers of the same kind. The product is China's GB2760-86 provisions for the allowed use of edible spices. Mainly used for the preparation of walnut, hazelnut and other nut-type flavor. The product is also used for the modulation of ylang ylang ylang, kanunga, Violet, narcissus, etc. It can also be used as an intermediate for other spices.
used in the preparation of walnut, hazelnut and other nut-type spices
spices, intermediates of spices.
production method is prepared by the methylation reaction of p-Cresol with dimethyl sulfate in the presence of sodium hydroxide. After the reaction, the product was obtained by neutralization and washing, separation by layers and distillation under reduced pressure. The process was similar to that of 2-methylanisole.
methylated from p-cresol.
category flammable liquid
toxicity grade poisoning
Acute toxicity oral-rat LD50: 1920 mg/kg
stimulation data Skin-rabbit 500 mg/24 h moderate
flammability hazard characteristics flammability; Combustion stimulus smoke
storage and transportation characteristics warehouse ventilation and low temperature drying
extinguishing agent dry powder, foam, sand, water
Occupational Standard SEL 10 mg/m3
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update:2024-04-10 22:29:15
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4-Methylanisole
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