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4-Methylphenylacetone

4-Methylphenylacetone

CAS: 2096-86-8

Molecular Formula: C10H12O

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4-Methylphenylacetone - Names and Identifiers

Name 4-Methylphenylacetone
Synonyms 4-METHYLPHENYLACETONE
4-Methylphenylacetone
(P-METHYLPHENYL)ACETONE
1-(4-Methylphenyl)acetone
4-Methyl benzene, acetone
1-(4-Methylphenyl)propan-2-one
1-(4-methylphenyl)propan-2-one
1-(4-Methylphenyl)propan-2-one, p-Tolylacetone
CAS 2096-86-8
InChI InChI=1/C10H12O/c1-8-3-5-10(6-4-8)7-9(2)11/h3-6H,7H2,1-2H3

4-Methylphenylacetone - Physico-chemical Properties

Molecular FormulaC10H12O
Molar Mass148.2
Density0.96
Boling Point132 °C
Flash Point97.1°C
Vapor Presure0.0982mmHg at 25°C
Storage ConditionSealed in dry,Room Temperature
Refractive Index1.5130 (estimate)

4-Methylphenylacetone - Risk and Safety

Safety Description24/25 - Avoid contact with skin and eyes.
WGK Germany3

4-Methylphenylacetone - Reference Information

preparation 1) synthesis process of propionyl chloride
250kg propionic acid and 185kg phosphorus trichloride were put into a 500L glass-lined reaction pot, and the reaction was slowly heated, stirred at 50 ℃ for 6h, and left for 3H, the lower phosphorous acid was separated, and 297kg of propionphthalein chloride was obtained, with a yield of 95%. The obtained propionphthalein chloride could be used for the next production without purification.
2) put 225kg of anhydrous aluminum trichloride and 160kg of toluene in a 500L glass-lined reaction Pan, cool the jacket, slowly add 120kg of propionphthalein chloride Dropwise with stirring, keep the internal temperature not higher than 30 ℃, after addition, stirring at room temperature for 1 H, then slowly raising the temperature to 82 ℃, keeping the temperature for 2H and then cooling, hydrolyzing the reaction droplets in a 2000L glass lining reaction pot containing It mixed with ice and water at low temperature, and layered at rest, take the upper oily substance, wash to Neutral with water and saturated soda ash solution, dry, remove toluene at atmospheric pressure, and then collect the 96-100 ℃/930Pa fraction to obtain 4-methylphenylacetone content greater than 98%, the yield was 88%.
Application 4-methylphenylpropanone is an important intermediate for the production of naomaining, its synthesis mechanism is a gram of Fu Fu acylation reaction, but due to the raw material toluene and ethylbenzene ring substituents on different, resulting in the ortho, Inter, P-phthalein product ratio difference, therefore, the choice of solvent, reaction time and temperature in the production process is different.
Last Update:2024-04-09 15:16:45
4-Methylphenylacetone
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Shanghai Macklin Biochemical Co., Ltd
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CAS: 2096-86-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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Mobile: 18916960931
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Wechat: chinaskyrun
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: 4-Methylphenylacetone Visit Supplier Webpage Request for quotation
CAS: 2096-86-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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View History
4-Methylphenylacetone
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