4-hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol
4-hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol
CAS: 368-54-7
Molecular Formula: C5H3F3N2OS
4-hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol - Names and Identifiers
4-hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol - Physico-chemical Properties
| Molecular Formula | C5H3F3N2OS |
| Molar Mass | 196.15 |
| Density | 1.63±0.1 g/cm3(Predicted) |
| Melting Point | 246-250 °C (lit.) |
| Solubility | soluble in Methanol |
| Appearance | Powder |
| Color | White to Almost white |
| Maximum wavelength(λmax) | ['270nm(MeOH)(lit.)'] |
| pKa | 6.21±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| MDL | MFCD00112978 |
4-hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29335990 |
| Hazard Class | IRRITANT |
4-hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| Introduction | 4-hydroxy-6-(trifluoromethyl) pyrimidin-2-mercaptan is a 4-hydroxy substituted pyrimidine compound, which occupies an important position in pharmaceutical and pesticide intermediates. |
| Uses | 4-hydroxy-6-(trifluoromethyl) pyrimidine-2-thiol is a pyrimidine derivative, which can be used to prepare anti-cancer, Antibacterial, anti-malarial, arthritis and other drugs; it can also be used for the synthesis of herbicides, pesticides, and fungicides. For example, drug molecules such as the antimalarial drug pyrimethamine, the antihypertensive drug minoxidil, the anti-cancer drug 5-fluorouracil, and the fungicides ethimurol and methylpyrimidine in pesticides all contain pyrimidine structures. |
| prepare | 250mL three-neck bottle, equipped with mechanical stirring and reflux condenser tube, add 27.6g(0.15mol) of ethyl trifluoroacetoacetate, 11.4g(0.15mol) of thiourea, 100mLDMF, heat to 120 ℃, and react for 4 hours. Cooling, recovery of solvent under reduced pressure, cooling and crystallization, filtration and washing with water to obtain 25.3g of 4-hydroxy-6-(trifluoromethyl) pyrimidin-2-mercaptan (yield: 86.0%). |
Last Update：2024-04-10 22:29:15
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View History
4-hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol
N2-[(tert-butoxy)carbonyl]-L-asparagine
AC-CYSTEINE(FARNESYL)-OH
3,5-Dichlorobenzene-1-thiol
(2E)-3-[4-(乙酰基氨基)苯基]丙烯酸
1-Bromo-3,5-dihydroxybenzene
2,5-Dichoro-p-benzoquinone
N2-[(tert-butoxy)carbonyl]-L-asparagine
AC-CYSTEINE(FARNESYL)-OH
3,5-Dichlorobenzene-1-thiol
(2E)-3-[4-(乙酰基氨基)苯基]丙烯酸
1-Bromo-3,5-dihydroxybenzene
2,5-Dichoro-p-benzoquinone