404-90-0
3-fluoro-4-methoxyphenylacetonitrile
CAS: 404-90-0
Molecular Formula: C9H8FNO
404-90-0 - Names and Identifiers
404-90-0 - Physico-chemical Properties
| Molecular Formula | C9H8FNO |
| Molar Mass | 165.16 |
| Density | 1.148±0.06 g/cm3(Predicted) |
| Melting Point | 46-48°C |
| Boling Point | 99-105 °C(Press: 0.5 Torr) |
| Flash Point | 117.5°C |
| Vapor Presure | 0.00676mmHg at 25°C |
| Appearance | Yellow-like crystals |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.501 |
| MDL | MFCD00040889 |
404-90-0 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 3439 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
404-90-0 - Introduction
It is an organic compound with the chemical formula C9H8FNO. Its structure contains a fluorine atom, a methoxy group and a nitrile group. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless or light yellow solid
-Melting point: about 40-42 degrees Celsius
-Boiling point: about 255-256 degrees Celsius
-Solubility: Soluble in some organic solvents, such as methanol, ethanol and dichloromethane
Use:
It can be used as an intermediate in organic synthesis, and is mainly used to prepare other compounds, such as drugs and pesticides. It has a certain activity and can participate in various reaction types, such as nucleophilic substitution and coupling reactions.
Preparation Method:
The preparation method can be achieved through the following steps:
1. At low temperature, 3-fluoro-4-methoxybenzeneacetaldehyde and sodium cyanide are reacted in a solvent.
2. After the reaction is completed, hydrolyze the nitrile group under acidic conditions (such as hydrochloric acid) to obtain the nitrile group.
Safety Information:
Toxicity and low risk, but still need to pay attention to the following aspects:
-Avoid contact with skin, eyes and mucous membranes.
-When using, should wear protective gloves and glasses.
-After operation or contact, the contaminated clothing should be thoroughly cleaned.
-When stored, it should be sealed and stored to avoid contact with oxidants and strong acids.
-Do not use in food, medicine or cosmetics.
Please note that the above information is for reference. Please refer to the relevant safety information of chemicals for specific operations.
Nature:
-Appearance: Colorless or light yellow solid
-Melting point: about 40-42 degrees Celsius
-Boiling point: about 255-256 degrees Celsius
-Solubility: Soluble in some organic solvents, such as methanol, ethanol and dichloromethane
Use:
It can be used as an intermediate in organic synthesis, and is mainly used to prepare other compounds, such as drugs and pesticides. It has a certain activity and can participate in various reaction types, such as nucleophilic substitution and coupling reactions.
Preparation Method:
The preparation method can be achieved through the following steps:
1. At low temperature, 3-fluoro-4-methoxybenzeneacetaldehyde and sodium cyanide are reacted in a solvent.
2. After the reaction is completed, hydrolyze the nitrile group under acidic conditions (such as hydrochloric acid) to obtain the nitrile group.
Safety Information:
Toxicity and low risk, but still need to pay attention to the following aspects:
-Avoid contact with skin, eyes and mucous membranes.
-When using, should wear protective gloves and glasses.
-After operation or contact, the contaminated clothing should be thoroughly cleaned.
-When stored, it should be sealed and stored to avoid contact with oxidants and strong acids.
-Do not use in food, medicine or cosmetics.
Please note that the above information is for reference. Please refer to the relevant safety information of chemicals for specific operations.
Last Update：2024-04-09 15:17:57
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