411238-88-5

411238-88-5 - Names and Identifiers

Name	tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate
Synonyms	Zinc01436154 Zinc01436155 1-BOC-PYRROLIDINE-3-CARBOHYDRAZIDE 1-BOC-3-HYDRAZINOCARBONYLPYRROLIDINE 1-Boc-3-hydrazinocarbonyl-pyrrolidine 1-Boc-pyrrolidine-3-carboxylic acid hydrazide tert-butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate 3-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-(hydrazinecarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
CAS	411238-88-5
InChI	InChI=1/C10H19N3O3/c1-10(2,3)16-9(15)13-5-4-7(6-13)8(14)12-11/h7H,4-6,11H2,1-3H3,(H,12,14)

411238-88-5 - Physico-chemical Properties

Molecular Formula	C10H19N3O3
Molar Mass	229.28
Density	1.180±0.06 g/cm3(Predicted)
Boling Point	395.8±31.0 °C(Predicted)
Flash Point	193.1°C
Vapor Presure	1.8E-06mmHg at 25°C
pKa	13.04±0.20(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.514

411238-88-5 - Risk and Safety

Risk Codes	22 - Harmful if swallowed
Hazard Class	IRRITANT

411238-88-5 - Introduction

tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate is an organic compound whose chemical formula is C12H21N3O3. It has the following properties:

1. Appearance: White crystalline solid.
2. Melting point: about 90-95°C.
3. Solubility: Soluble in organic solvents such as dimethylformamide (DMF) and dichloromethane.

tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate have many uses in the field of drug synthesis, including the following:

1. Provide hydrazine group: Hydrazine group is a commonly used reaction intermediate, which can be used to synthesize other biologically active compounds.
2. protection of nitrogen atom: by Boc(t-butoxycarbonyl) protecting group, the nitrogen atom in the compound can be selectively protected to prevent them from accidental reaction during the reaction.
3. Synthesis of targeted drugs: tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate can be used to synthesize compounds with specific drug target activity from lead compounds.

The preparation method of tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate generally includes the following steps:

1. First, pyrrolidine undergoes a base-catalyzed ring-closing reaction to generate 3-pyrrolidine formaldehyde.
2. Next, 3-pyrrolidinecarboxaldehyde is reacted with hydrazine to form the product tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate.

Regarding safety information, tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate currently has no specific hazard information publicly available. However, as a chemical, use should follow general laboratory safety practices, ensure good ventilation, and use personal protective equipment, such as laboratory gloves and protective glasses.

Last Update：2024-04-09 21:01:54