41372-20-7

41372-20-7 - Names and Identifiers

Name	R-(-)-Apomorphine
Synonyms	R-(-)-Apomorphine APOMORPHINEHCLHEMIHYDRATE 6a-beta-aporphine-10,11-diol Apomorphine hydrochloride R-(-)- APOMORPHINE HYDROCHLORIDE, HEMIHYDRATE APOMORPHINEHYDROCHLORIDE,HEMIHYDRATE,USP (r)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo[de,g]quinoline-10,11-diol (6Ar)-5,6,6A,7-tetrahydro-6-methyl-4H-dibenzo(de,G)chinolin-10,11-diol hydrochlorid 4H-Dibenzode,gquinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, hydrate (2-1), (6aR)-
CAS	41372-20-7
EINECS	627-402-4

41372-20-7 - Physico-chemical Properties

Molecular Formula	C17H17NO2
Molar Mass	267.32
Melting Point	285-287 °C(lit.)
Appearance	Shape calcined, color white to gray
PH	pH(10g/l, 25℃) : 4.0～5.0
Storage Condition	Refrigerator
Physical and Chemical Properties	The chemical product is a white fine crystalline powder. Melting point 285-287 ℃. 1 gram of powder can be dissolved in 50 ml of water, 17 ml of 80 ℃ water, 50 ml of ethanol, slightly soluble in chloroform and ether. 1: The pH value of the 300 aqueous solution is 4.8. When exposed to light and air, it will decompose and turn green.
Use	Use this product is an emetic drug.

41372-20-7 - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
Safety Description	36 - Wear suitable protective clothing.
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3
HS Code	2933997000

41372-20-7 - Upstream Downstream Industry

Raw Materials

Sodium sulfite
CHLOROETHANE
Activated carbon,decolor
MORPHINE

41372-20-7 - Production method

It is derived from morphine by elimination, rearrangement, and salt formation. Add morphine to phosphoric acid, heat in water bath, and the internal temperature does not exceed 50 ℃. Stir until fully dissolved. Cooling is placed in an absorption tank, and hydrogen chloride gas is introduced until the reaction liquid weighs 2.5 times the amount of morphine. Move it into the reaction tank, continue to introduce hydrogen chloride gas, and heat it to 124-126 ℃ at the same time, and heat it for 3 hours. Put the reaction solution into ice water, cool to below 20°C, and slowly add sodium carbonate under stirring until the gel is completely precipitated. Divide the jelly into concentrated hydrochloric acid, dissolve the jelly hydrochloride in boiling water, then add the sodium sulfite solution, and extract it twice with dichloroethane-isopropanol mixed solvent. Concentrated hydrochloric acid was added to the extract under stirring to precipitate the crude product. The crude product is soaked in concentrated hydrochloric acid, dissolved in hot distilled water, decolorized with activated carbon, vacuum drying and other steps to obtain the finished product.

Last Update：2024-04-09 19:04:55