42017-89-0
2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionic acid
CAS: 42017-89-0
Molecular Formula: C17H15ClO4
42017-89-0 - Names and Identifiers
| Name | 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionic acid |
| Synonyms | FA Fenofibric acid FENOFIBRIC ACID FENOFIBRATE ACID Fenofibrate Acid SALOR-INT L498335-1EA LABOTEST-BB LT00239222 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionic acid 2-[4-(4-CHLOROBENZOYL)PHENOXY]-2-METHYLPROPANOIC ACID 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-Propanoic acid 2-[4'-(p-Chlorobenzoyl)phenoxy]-2-methylpropionic acid 2-[4-(4-CHLOROBENBONYZOYL)PHENOXY)-2-METHYLPROPIONIC ACID 2-{4-[(4-chlorophenyl)carbonyl]phenoxy}-2-methylpropanoate 2-[4-(4-CHLORO-BENZOYL)-PHENOXY]-2-METHYL-PROPIONIC ACID (FENOFIBRIC ACID) |
| CAS | 42017-89-0 |
| EINECS | 255-626-9 |
| InChI | InChI=1/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21)/p-1 |
42017-89-0 - Physico-chemical Properties
| Molecular Formula | C17H15ClO4 |
| Molar Mass | 318.75 |
| Density | 1.286±0.06 g/cm3(Predicted) |
| Melting Point | 177-179°C |
| Boling Point | 486.5±35.0 °C(Predicted) |
| Flash Point | 248°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 2.82E-10mmHg at 25°C |
| Appearance | White to white-like solid |
| Color | White to Off-White |
| BRN | 2058973 |
| pKa | 3.09±0.10(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD00792461 |
| In vitro study | Fibric acids, the activated form of lipid-lowering drugs, are also agonists of PPAR alpha, which has the effect of raising high-density lipoprotein. Fibriic acids enhance fatty acid catabolism and lower blood lipid levels-primarily triglyceride levels. It upregulates ABCA1 expression and apoA-I-mediated HDL production. The Fibric acids exert their effect on ABCA1 expression by enhancing the transcription of the LXR-dependent ABCA1 gene. |
| In vivo study | Fenofibriic acid attenuates the abnormal increase of circulating endothelial progenitor cells (EPC) in OIR mice. Its inhibitory effect on EPC mobilization is dependent on PPAR α. Fenofibriic acid inhibits hypoxia-induced increase in retinal endothelial progenitor cells, reduces the number of circulating CXCR4 positive EPC, down-regulates serum SDF-1 levels and inhibits the overexpression of HIF-1a and SDF-1 in the retina. |
42017-89-0 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S60 - This material and its container must be disposed of as hazardous waste. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | UA2453000 |
| HS Code | 29189900 |
| Hazard Class | 9 |
| Packing Group | III |
| Toxicity | LD50 oral in rat: 1242mg/kg |
42017-89-0 - Reference Information
| biological activity | Fenofibric acid (NSC 281318, Trilipix, FNF acid) is a lipid-lowering agent that reduces low density lipoprotein cholesterol and triglyceride. |
| Target | Value |
| Use | Used as a pharmaceutical intermediate An intermediate of fenofibrate. Fenofibric acid is the active metabolite of Fenofibrate (F248640). Increases Apolipoprotein A- I holmium ediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transpor ter A1 gene in a liver X receptor holmium ependent banner. |
Last Update：2024-04-09 21:32:06
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