425378-68-3

425378-68-3 - Names and Identifiers

Name	2-Fluoro-5-nitrophenylboronicacidpinacolester
Synonyms	174905 2-Fluoro-5-nitrophenylboronicacidpinacolester 2-FLUORO-5-NITROPHENYLBORONIC ACID PINACOL ESTER 2-Fluoro-5-Nitrophenylboronic Acid Pinacol Ester 2-Fluoro-5-nitrobenzeneboronic acid, pinacol ester 1,3,2-Dioxaborolane,2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl- 2-(2-FLUORO-5-NITROPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLANE 4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene 1,3,2-Dioxaborolane, 2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-
CAS	425378-68-3
InChIKey	FXEVKZIXXGDLFW-UHFFFAOYSA-N

425378-68-3 - Physico-chemical Properties

Molecular Formula	C12H15BFNO4
Molar Mass	267.06
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

425378-68-3 - Risk and Safety

Hazard Symbols	Xi - Irritant
WGK Germany	3
Hazard Note	Irritant

425378-68-3 - Reference Information

Application

2-fluoro-5-nitrophenylboronic acid pinacol ester is an ester organic substance, which is an organic intermediate. It can be obtained by the reaction of 2-bromo-1-fluoro-4-nitrobenzene and pinacol biborate, which can be used for Suzuki reaction.

preparation

2-bromo-1-fluoro-4-nitrobenzene (13.2g,60mmol),4,4,4 ',4',5,5 ',5',5 '-octamethyl -2,2'-union (1,3,2-dioxboropentane)(22.8g,90mmol),[1,1 '-bis (diphenylphosphine) ferrocene] palladium dichloride (880mg,12mmol), potassium acetate (17.6g,180mmol) dissolved in 1,4-dioxane (180mL), replaced nitrogen, heated to 90 ℃ and stirred overnight, LC/MS detection reaction was complete. Water (150mL) was added to the reaction solution, extracted with ethyl acetate (200mL), the organic phase was washed with saturated salt water (150mL * 2), dried with anhydrous sodium sulfate, concentrated and purified with silica gel preparation chromatography (petroleum ether: ethyl acetate = 10:1) to obtain 2-fluoro-5-nitrophenylborate pinacyl ester (14.0g, yield 87.3%).

Last Update：2024-04-09 02:00:05