436133-68-5
N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide
CAS: 436133-68-5
Molecular Formula: C15H11ClF3N5O4S
436133-68-5 - Names and Identifiers
436133-68-5 - Physico-chemical Properties
| Molecular Formula | C15H11ClF3N5O4S |
| Molar Mass | 449.79 |
| Melting Point | >166°C (dec.) |
| Solubility | DMSO: soluble15mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| In vitro study | The compounds of the Kobe0065 family bind to Ras-GTP and have anti-proliferative activity against cancer cells carrying an activated ras oncogene. It effectively inhibits the interaction of Ras ~ GTP with its effector proteins such as Raf, PI3K, RalGDS and the regulator/effector Sos, with a broad binding specificity for various small GTPases of the Ras family. |
| In vivo study | Kobe0065 has anti-tumor activity. Tumors treated with this compound significantly increased their apoptotic cells without significant weight loss. |
436133-68-5 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
436133-68-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.223 ml | 11.116 ml | 22.233 ml |
| 5 mM | 0.445 ml | 2.223 ml | 4.447 ml |
| 10 mM | 0.222 ml | 1.112 ml | 2.223 ml |
| 5 mM | 0.044 ml | 0.222 ml | 0.445 ml |
Last Update：2024-01-02 23:10:35
436133-68-5 - Reference Information
| biological activity | Kobe0065 is an inhibitor of H-Ras-cRaf1 interaction and can effectively inhibit the combination of H-Ras · GTP and c-Raf-1 RBD with a Ki value of 46±13 μM. |
| target | TargetValue H-Ras-cRaf1 interaction () |
| Target | Value |
| in vitro study | Kobe0065 family compounds bind to Rasevents and have anti-proliferative activity against cancer cells carrying the ras-activated oncogene. It effectively inhibits the interaction of RasaS GTP with its effector proteins such as Raf, PI3K, RalGDS and regulatory/effector Sos, and has a wide range of binding specificity for small GTP enzymes of various Ras families. |
| in vivo research | Kobe0065 have anti-tumor activity. Tumors treated with this compound significantly increased their apoptotic cells without significant weight loss. |
Last Update：2024-04-10 22:29:15
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Product Name: Kobe0065 Visit Supplier Webpage Request for quotationCAS: 436133-68-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Kobe0065 Request for quotationCAS: 436133-68-5
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide Visit Supplier Webpage Request for quotationCAS: 436133-68-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Kobe0065 Visit Supplier Webpage Request for quotationCAS: 436133-68-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide Visit Supplier Webpage Request for quotationCAS: 436133-68-5
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View History
436133-68-5
R-叔亮氨醇
215433-52-6
D-p-Methyl
101-80-4
10177-29-4
78952-72-4
Chlorinated polyethylene,rolled
MAC GLUCURONIDE LINKER-1
烟酸钠盐
R-叔亮氨醇
215433-52-6
D-p-Methyl
101-80-4
10177-29-4
78952-72-4
Chlorinated polyethylene,rolled
MAC GLUCURONIDE LINKER-1
烟酸钠盐