444120-95-0

444120-95-0 - Names and Identifiers

Name	2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Synonyms	2-Flouropyridine-5-boronic acid pinacol ester 2-Fluoro-5-pyridineboronic acid pinacol ester 2-Fluoropyridine-5-boronic acid pinacol ester 6-FLUOROPYRIDINE-3-BORONIC ACID, PINACOL ESTER 2-Fluoropyridin-5-ylboronic acid pinacol ester 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-Fluoro-5-pyridineboronic acid pinacol ester, 2-Fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-pyridine
CAS	444120-95-0
InChI	InChI=1/C11H15BFNO2/c1-10(2)11(3,4)16-12(15-10)8-5-6-9(13)14-7-8/h5-7H,1-4H3

444120-95-0 - Physico-chemical Properties

Molecular Formula	C11H15BFNO2
Molar Mass	223.05
Density	1.09±0.1 g/cm3(Predicted)
Melting Point	29-33°C(lit.)
Boling Point	304.2±27.0 °C(Predicted)
Flash Point	>230°F
Vapor Presure	0.002mmHg at 25°C
Appearance	powder to lump
Color	White to Light yellow
pKa	-0.44±0.12(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.477

444120-95-0 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3

444120-95-0 - Introduction

2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is an organic compound whose chemical formula is C11H16BFNO2.

Nature:
The compound is a colorless solid and has high stability at room temperature.
It has low solubility and can be dissolved in organic solvents such as methanol, ethanol and dichloromethane.

Use:
2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a compound containing a boronic acid group and has a wide range of applications.
It can be used as an important reagent in organic synthesis, and is often used in nucleophilic substitution reactions, coupling reactions and catalytic reactions in chemical synthesis.
In addition, it can also be used as a catalyst to play the role of a catalyst in organic synthesis and promote the progress of the reaction.

Preparation Method:
2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine can be synthesized by the following steps:

1. First, 2-fluoropyridine is reacted with boronic acid pinacol ester to generate 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine in dichloromethane.

2. The solid product was then filtered, washed and dried.

3. Finally, the target product was purified by recrystallization or column chromatography.

Safety Information:
2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine has high safety, but the following matters still need to be paid attention:

1. it should be stored in a cool, dry place, away from fire and oxidant.

2. in use, should wear appropriate personal protective equipment, such as laboratory gloves, safety glasses and protective clothing.

3. Avoid direct contact with skin and eyes. If splashed into eyes or swallowed, rinse immediately with plenty of water and seek medical help.

4. When disposing of waste, it should be disposed in accordance with local regulations to avoid environmental pollution.

Last Update：2024-04-10 22:29:15

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