4498-68-4
Ethyl 1H-indazole-3-carboxylate
CAS: 4498-68-4
Molecular Formula: C10H10N2O2
4498-68-4 - Names and Identifiers
| Name | Ethyl 1H-indazole-3-carboxylate |
| Synonyms | ethyl 1H-indazole-3-carboxylate Ethyl 1H-indazole-3-carboxylate 3-Indazolecarboxylic acid ethyl ester Indazole-3-carboxylic acid ethyl ester 1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 1H-Indazole-3-carboxylic acid ethyl ester 1-Benzyl-3-indazolecarboxylic acid ethyl ester |
| CAS | 4498-68-4 |
| EINECS | 224-795-0 |
| InChI | InChI=1/C10H10N2O2/c1-2-14-10(13)9-7-5-3-4-6-8(7)11-12-9/h3-6H,2H2,1H3,(H,11,12) |
4498-68-4 - Physico-chemical Properties
| Molecular Formula | C10H10N2O2 |
| Molar Mass | 190.2 |
| Density | 1.272±0.06 g/cm3(Predicted) |
| Melting Point | 136-138℃ |
| Boling Point | 353.9±15.0 °C(Predicted) |
| Flash Point | 167.8°C |
| Vapor Presure | 3.47E-05mmHg at 25°C |
| Appearance | White crystal |
| pKa | 11.93±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.627 |
| MDL | MFCD01138134 |
4498-68-4 - Risk and Safety
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
| HS Code | 29339900 |
4498-68-4 - Introduction
Ethyl 1H-indazole-3-carboxylate(Ethyl 1H-indazole-3-carboxylate) is an organic compound with the chemical formula C11H10N2O2.
Its properties are as follows:
Appearance: Colorless to light yellow liquid
Melting point: 50-52°C
Boiling point: 340-342°C
Density: 1.27g/cm3
Ethyl 1H-indazole-3-carboxylate is mainly used as follows:
1. as an intermediate in the synthesis of heterocyclic compounds, it is used to prepare other indazole compounds.
2. It has certain research value in the field of medicine, and can be used as potential antibacterial and anti-inflammatory drugs.
Ethyl 1H-indazole-3-carboxylate is usually prepared by the following steps:
Indazole-3-carboxylic acid is reacted with an acid anhydride and an alcohol to produce an esterified product. The reaction is usually carried out under basic conditions using DCC (dithiocarbonyldiazine) or EDCI (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide) as an activator. Finally, the target product was obtained by titration dilute acid hydrolysis.
Regarding the safety information of Ethyl 1H-indazole-3-carboxylate, the following matters need to be noted:
1. As an organic compound, it has certain toxicity and irritation. Appropriate protective measures, including goggles and gloves, should be worn during operation.
2. During storage and use, avoid contact with fire and high temperature to avoid burning or explosion.
3. avoid contact with strong oxidants, strong acids or strong bases to prevent dangerous reactions.
4. Store Ethyl 1H-indazole-3-carboxylate in an airtight container, away from open flames, and in a cool, dry place. Avoid direct sunlight.
Its properties are as follows:
Appearance: Colorless to light yellow liquid
Melting point: 50-52°C
Boiling point: 340-342°C
Density: 1.27g/cm3
Ethyl 1H-indazole-3-carboxylate is mainly used as follows:
1. as an intermediate in the synthesis of heterocyclic compounds, it is used to prepare other indazole compounds.
2. It has certain research value in the field of medicine, and can be used as potential antibacterial and anti-inflammatory drugs.
Ethyl 1H-indazole-3-carboxylate is usually prepared by the following steps:
Indazole-3-carboxylic acid is reacted with an acid anhydride and an alcohol to produce an esterified product. The reaction is usually carried out under basic conditions using DCC (dithiocarbonyldiazine) or EDCI (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide) as an activator. Finally, the target product was obtained by titration dilute acid hydrolysis.
Regarding the safety information of Ethyl 1H-indazole-3-carboxylate, the following matters need to be noted:
1. As an organic compound, it has certain toxicity and irritation. Appropriate protective measures, including goggles and gloves, should be worn during operation.
2. During storage and use, avoid contact with fire and high temperature to avoid burning or explosion.
3. avoid contact with strong oxidants, strong acids or strong bases to prevent dangerous reactions.
4. Store Ethyl 1H-indazole-3-carboxylate in an airtight container, away from open flames, and in a cool, dry place. Avoid direct sunlight.
Last Update：2024-04-09 19:05:49
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