458-50-4
4-Bromo-3-fluoroanisole
CAS: 458-50-4;408-50-4
Molecular Formula: C7H6BrFO
458-50-4 - Names and Identifiers
| Name | 4-Bromo-3-fluoroanisole |
| Synonyms | FR BE EO1 4-Bromo-3-fluoroanisole 4-BROMO-3-FLUOROANISOLE 1-Brom-2-fluor-4-methoxybenzol 1-Bromo-2-fluoro-4-methoxybenzene 4-Bromo-3-fluorophenyl methyl ether Benzene, 1-bromo-2-fluoro-4-methoxy- |
| CAS | 458-50-4 408-50-4 |
| InChI | InChI=1/C7H6BrFO/c1-10-5-2-3-6(8)7(9)4-5/h2-4H,1H3 |
458-50-4 - Physico-chemical Properties
| Molecular Formula | C7H6BrFO |
| Molar Mass | 205.02 |
| Density | 1.531g/cm3 |
| Melting Point | 217-219℃ |
| Boling Point | 195.4°C at 760 mmHg |
| Flash Point | 85.4°C |
| Vapor Presure | 0.59mmHg at 25°C |
| Storage Condition | Room Temprature |
| Refractive Index | 1.518 |
| MDL | MFCD01310983 |
458-50-4 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R52 - Harmful to aquatic organisms |
458-50-4 - Introduction
4-Bromo-3-fluoroanisole is an organic compound with the chemical formula C7H6BrFO. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 4-Bromo-3-fluoroanisole is a colorless or pale yellow liquid.
-melting point: about <-20 ℃.
-Boiling point: about 162-164 ℃.
-Solubility: Soluble in a variety of organic solvents, such as ether and ester solvents.
Use:
- 4-Bromo-3-fluoroanisole is an important organic synthesis intermediate, commonly used in the synthesis of drugs and pesticides.
-It can also be used for fluorine substitution reactions in organic synthesis reactions as a source of fluoride ions.
Preparation Method:
- 4-Bromo-3-fluoroanisole can be synthesized by the reaction of anisole with bromine and sodium fluoride. First, the sodium salt of anisole is obtained by reaction with sodium fluoride under alkaline conditions, and then the target product is obtained by reaction with bromine.
Safety Information:
- 4-Bromo-3-fluoroanisole has low toxicity and danger, but it is still necessary to pay attention to safe operation.
-Avoid contact with skin and eyes during handling. It is recommended to wear appropriate protective gloves and goggles.
-Should be used in a well-ventilated place, and away from fire and high temperature.
-In handling and storage, to strictly comply with the relevant safety regulations and fire regulations.
Please note that the use of chemicals in chemical experiments requires strict compliance with appropriate safety procedures.
Nature:
-Appearance: 4-Bromo-3-fluoroanisole is a colorless or pale yellow liquid.
-melting point: about <-20 ℃.
-Boiling point: about 162-164 ℃.
-Solubility: Soluble in a variety of organic solvents, such as ether and ester solvents.
Use:
- 4-Bromo-3-fluoroanisole is an important organic synthesis intermediate, commonly used in the synthesis of drugs and pesticides.
-It can also be used for fluorine substitution reactions in organic synthesis reactions as a source of fluoride ions.
Preparation Method:
- 4-Bromo-3-fluoroanisole can be synthesized by the reaction of anisole with bromine and sodium fluoride. First, the sodium salt of anisole is obtained by reaction with sodium fluoride under alkaline conditions, and then the target product is obtained by reaction with bromine.
Safety Information:
- 4-Bromo-3-fluoroanisole has low toxicity and danger, but it is still necessary to pay attention to safe operation.
-Avoid contact with skin and eyes during handling. It is recommended to wear appropriate protective gloves and goggles.
-Should be used in a well-ventilated place, and away from fire and high temperature.
-In handling and storage, to strictly comply with the relevant safety regulations and fire regulations.
Please note that the use of chemicals in chemical experiments requires strict compliance with appropriate safety procedures.
Last Update：2024-04-09 19:05:49
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