473278-54-5
2-amino-9-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]-1H-purin-6-one
CAS: 473278-54-5
Molecular Formula: C13H19N5O6
473278-54-5 - Names and Identifiers
| Name | 2-amino-9-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]-1H-purin-6-one |
| Synonyms | 2'-MOE-rG 2'-O-MOE-rG 2'-O-MOE-Gr 2'-O-Methoxyethyl-guanosine 2'-O-(2-Methoxyethyl)guanosine 2'-O-(2-Methoxyethyl)Guanosine 2'-O-(2-methoxyethyl)-guanosine Guanosine, 2'-O-(2-Methoxyethyl)- 2-amino-9-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]-1H-purin-6-one 2-amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one |
| CAS | 473278-54-5 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C13H19N5O6/c1-22-2-3-23-9-8(20)6(4-19)24-12(9)18-5-15-7-10(18)16-13(14)17-11(7)21/h5-6,8-9,12,19-20H,2-4H2,1H3,(H3,14,16,17,21)/t6-,8+,9+,12-/m1/s1 |
473278-54-5 - Physico-chemical Properties
| Molecular Formula | C13H19N5O6 |
| Molar Mass | 341.32 |
| Density | 1.81±0.1 g/cm3(Predicted) |
| Boling Point | 715.0±70.0 °C(Predicted) |
| pKa | 13.20±0.70(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.745 |
473278-54-5 - Introduction
2-amino-9-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]-1H-purin-6-one is a compound whose chemical name is 2-amino-9-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl -3. The following is an introduction to its nature, use, formulation and safety information:
Nature:
-Appearance: White or off-white solid
-Molecular formula: C15H21N5O6
-Molecular weight: 383.36g/mol
-melting point: 215-218 ℃
-Solubility: Soluble in water, slightly soluble in ethanol and acetone
Use:
- 2-amino-9-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]-1H-purin-6-one is a nucleoside compound, It has a wide range of applications in biochemical research and drug development. It is commonly used as a guanylate synthase inhibitor.
Preparation Method:
The preparation of -2-amino-9-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]-1H-purin-6-one is usually carried out by an organic synthesis method. One possible synthetic route is to first synthesize the relevant precursor compounds, followed by esterification or nucleosidation under appropriate conditions.
Safety Information:
- 2-amino-9-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]-1H-purin-6-one has limited toxicity and safety information, so care should be taken when using it. It may be irritating and toxic to the human body, so skin contact and inhalation should be avoided. Appropriate protective measures must be taken during use and handling, such as wearing protective gloves, goggles and protective clothing. Any waste associated with this compound must be treated and disposed of in accordance with local regulations. When used in the laboratory, it is recommended to follow safe operating procedures.
Nature:
-Appearance: White or off-white solid
-Molecular formula: C15H21N5O6
-Molecular weight: 383.36g/mol
-melting point: 215-218 ℃
-Solubility: Soluble in water, slightly soluble in ethanol and acetone
Use:
- 2-amino-9-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]-1H-purin-6-one is a nucleoside compound, It has a wide range of applications in biochemical research and drug development. It is commonly used as a guanylate synthase inhibitor.
Preparation Method:
The preparation of -2-amino-9-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]-1H-purin-6-one is usually carried out by an organic synthesis method. One possible synthetic route is to first synthesize the relevant precursor compounds, followed by esterification or nucleosidation under appropriate conditions.
Safety Information:
- 2-amino-9-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]-1H-purin-6-one has limited toxicity and safety information, so care should be taken when using it. It may be irritating and toxic to the human body, so skin contact and inhalation should be avoided. Appropriate protective measures must be taken during use and handling, such as wearing protective gloves, goggles and protective clothing. Any waste associated with this compound must be treated and disposed of in accordance with local regulations. When used in the laboratory, it is recommended to follow safe operating procedures.
Last Update：2024-04-09 20:49:11
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