477-47-4
Picropodophyllotoxin
CAS: 477-47-4
Molecular Formula: C22H22O8
477-47-4 - Names and Identifiers
| Name | Picropodophyllotoxin |
| Synonyms | (-)PPP NSC 36407 PICROPODOPHYLLIN Picropodophyllotoxin IGF-1R Inhibitor, PPP POLY(2,5-BIS(3-SULFONATOPROPOXY)-1,4-PHENYLENE, DISODIUM SALT-ALT-1,4-PHENYLENE) |
| CAS | 477-47-4 |
477-47-4 - Physico-chemical Properties
| Molecular Formula | C22H22O8 |
| Molar Mass | 414.41 |
| Density | 1.370 |
| Melting Point | 225-227℃ |
| Boling Point | 453.31°C (rough estimate) |
| Specific Rotation(α) | D20 +9.4° (c = 0.7 in chloroform) |
| Solubility | Soluble in DMSO, insoluble in water |
| Appearance | Powder |
| Color | white |
| pKa | 13.26±0.40(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Sensitive | Light Sensitive |
| Refractive Index | 1.4480 (estimate) |
| MDL | MFCD01742647 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, comes from the rhizome of Berberis plant octagonal lotus Dysosma versipellis(Hance.)M.Cheng, peach seven. |
| In vitro study | In intact cells, PPP potently inhibited IGF-1 of Akt (Ser 473) and Erk1/2 phosphorylation stimulated by IGF-1R. In IGF-1R positive tumor cells in culture, picropodophylin specifically inhibited cell growth and induced apoptosis. Picropodopylin synergistically sensitized HMCL, primary human MM and mouse 5T33MM cells to ABT-737 and ABT-199 by further reducing cell viability and enhancing apoptosis. Picropodopylin and sorafenib synergistically inhibit the proliferation and activity of hepatocellular carcinoma. |
| In vivo study | In SCID mice xenografted with human ES-1,BE, and PC3, Picropodophyllin (20 mg/kg/12 h, I. p.) caused complete tumor regression. In the 5t33mm mouse model, Picropodophyllin also showed potent anti-tumor activity and significantly increased survival. |
477-47-4 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R68 - Possible risk of irreversible effects R25 - Toxic if swallowed R21 - Harmful in contact with skin |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | LV2510000 |
| Hazard Class | 6.1 |
| Toxicity | LD50 intraperitoneal in mouse: 280mg/kg |
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