481-49-2
cepharanthine
CAS: 481-49-2
Molecular Formula: C37H38N2O6
481-49-2 - Names and Identifiers
| Name | cepharanthine |
| Synonyms | Stephanotis cepharanthine 22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2~16,19~.1~3,10~.1~21,25~.0~4,8~.0~14,39~.0~31,35~]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene (non-preferred name) (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2~16,19~.1~3,10~.1~21,25~.0~4,8~.0~14,39~.0~31,35~]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene (non-preferred name) |
| CAS | 481-49-2 |
| InChI | InChI=1/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3 |
481-49-2 - Physico-chemical Properties
| Molecular Formula | C37H38N2O6 |
| Molar Mass | 606.72 |
| Density | 1.227g/cm3 |
| Melting Point | 145-155° |
| Boling Point | 654.03°C (rough estimate) |
| Specific Rotation(α) | D20 +277° (c = 2 in chloroform) |
| Solubility | DMSO : 125 mg/mL (206.03 mM; Need ultrasonic) |
| Appearance | White crystal |
| pKa | 7.61±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.608 |
| MDL | MFCD00210482 |
| Use | Used as an analgesic, can be used to promote the proliferation of white blood cells. |
481-49-2 - Risk and Safety
| Toxicity | Toxic |
481-49-2 - Reference
| Reference Show more | 1. Yin, yang, Feng, Lei Jiang. Effect of makinin on proliferation and apoptosis of cervical cancer cells by regulating MAPK signaling pathway through MAT2B [J]. China Medical Biotechnology 2020 15(02):183-189. 2. [IF = 5.64] Wu Dousheng et al."Oleanolic acids the Type III secret System of Ralstonia solanacearum." Front Microbiol. 2015 Dec;0:1466 3. [IF = 4.739] Xu Zhang et al."Cepharanthine, a novel selective ANO1 inhibitor with potential for lung adenocarcinoma therapy." Bba-Mol Cell Res. 2021 Nov;1868:119132 4. [IF = 3.575] Xiang-Yan Wei et al."Antinociceptive activities and mechanism of action of Cepharanthine."BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2022 May ;: |
481-49-2 - Preparation Method
Open Data Verified Data
- 1kg of the root powder of the root of the ground was taken, and 0.6L5% Na2 C03 solution after wetting placed 2H, dry, so that plant tissues fully absorb the alkali solution, and then use benzene 1. 5L after soaking for 3 days, filter, the residue is bubbled with benzene for 2 days, after filtering, the residue is soaked with the same amount of benzene once, the benzene liquid is collected and combined for 3 times, and extracted with 10% hydrochloric acid, in the process of acid extraction, a large number of white atheroma precipitates and is easy to emulsify. The benzene liquid was extracted with acid until it did not contain alkaloids. The extracted acid liquid was basified with saturated Na2 C03 liquid, and the alkali solution was extracted with chloroform for 4 times. The chloroform extract was combined and dried over anhydrous sodium sulfate. The chloroform was distilled and recovered to obtain a light yellow foamy total alkaloid, weighing about 17. 5g. Then the total alkali was dissolved in 35mL acetone, placed for 2H, white needle-like crystals could be precipitated, filtered, washed with a small amount of acetone for 1 time, and dried to obtain 1. 8g of crenyline.
- 2.5 ml of benzene was added to the above acetone mother liquor, and the mixture was left standing overnight to precipitate columnar crystals. The crystals were filtered and washed once with acetone. It was then dissolved in chloroform, passed through an alumina column (lg of alkaloid with 3G of alumina), concentrated, and the resulting precipitate was filtered and dried to give a pale yellow foam-like amorphous powder, I .e.
Last Update：2022-01-01 11:15:05
481-49-2 - Application
Open Data Verified Data
clinical trial in the prevention and treatment of chemotherapy and radiotherapy induced leukopenia.
Last Update：2025-08-19 16:24:40
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