486460-00-8

486460-00-8 - Names and Identifiers

Name	[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-benzenebutanoic acid
Synonyms	(R)-Sitagliptin N-Boc-Acid IMpurity Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoicacid Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)-butyric acid (R)-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid boc-(r)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID (R)-N-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid (3R)-N-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid [[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-(R)-benzenebuta (3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid (3r)-n-(tert-butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid [[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-benzenebutanoic acid Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,(bR)- Benzenebutanoic acid,3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (3R)- (3r)-3-(1,1-dimethylethoxy carbonyl) amino]-4-(2,4,5-trifluorophenyl) butanoic acid Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid (3R)-N-(tert-Butoxycarbonyl)-3-aMino-4-(2,4,5-trifluorophenyl)-butanoic acid- Boc-(R)-3-AMino-4-(2,4,5-trifluorophenyl) butanoic acid (BOC acid)
CAS	486460-00-8
EINECS	691-120-8
InChI	InChI=1/C15H18F3NO4/c1-15(2,3)23-14(22)19-9(6-13(20)21)4-8-5-11(17)12(18)7-10(8)16/h5,7,9H,4,6H2,1-3H3,(H,19,22)(H,20,21)/t9-/m1/s1

486460-00-8 - Physico-chemical Properties

Molecular Formula	C15H18F3NO4
Molar Mass	333.31
Density	1.292±0.06 g/cm3(Predicted)
Melting Point	136-138℃
Boling Point	443.1±45.0 °C(Predicted)
Flash Point	221.8°C
Solubility	Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slig
Vapor Presure	1.25E-08mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	4.30±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.494
Use	Sitagliptin intermediate

486460-00-8 - Risk and Safety

Hazard Class

IRRITANT

486460-00-8 - Reference Information

Introduction

Boc-(R)-3-amino -4-(2,4, 5-trifluorophenyl) butyric acid is an important intermediate for the preparation of sitagliptin, cetagliptin phosphate (Sitagliptin
phosphate) is the first dipeptidyl enzyme-IV(DPP-4) inhibitor approved by FDA in 2006. It is used to treat type II diabetes. It can be used alone or in combination with metformin and pioglitazone. Both have obvious hypoglycemic effects, and are safe to take, well tolerated, and have few adverse reactions.

application

Boc-(R)-3-amino -4-(2,4, 5-trifluorophenyl) butyric acid white powder can be used as an organic synthesis intermediate and a chemical and pharmaceutical intermediate, dipeptidyl peptide -4 (DPP4) inhibitors, such as sitagliptin, can be used in laboratory research and development processes and for type 2 diabetes.

Last Update：2024-04-10 22:31:16

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