5-BroMo-1H-indazole-3-car...
5-Bromo-1H-Indazole-3-Carboxylic Acid
CAS: 1077-94-7
Molecular Formula: C8H5BrN2O2
5-BroMo-1H-indazole-3-car... - Names and Identifiers
5-BroMo-1H-indazole-3-car... - Physico-chemical Properties
| Molecular Formula | C8H5BrN2O2 |
| Molar Mass | 241.04 |
| Density | 1.946±0.06 g/cm3(Predicted) |
| Melting Point | 289-292°C |
| Boling Point | 493.4±25.0 °C(Predicted) |
| Flash Point | 252.176°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Crystalline powder |
| pKa | 2.81±0.30(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.766 |
| MDL | MFCD05663979 |
5-BroMo-1H-indazole-3-car... - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Hazard Note | Irritant |
5-BroMo-1H-indazole-3-car... - Reference Information
| uses | various derivatives of indazole -3-carboxylic acid also have biological activities such as anti-spermatogenesis, anti-arthritis and antiemetic activities, among which granisetron hydrochloride is a highly selective 5-HT, receptor antagonist, which has been widely used to prevent and treat nausea and vomiting caused by chemotherapy in tumor patients. In recent years, with the rapid development of the pharmaceutical industry, 5-bromoindazole -3-carboxylic acid as an important chemical product has received more and more attention. |
| Preparation | Method for synthesizing 5-bromoindazole-3-formic acid with 5-bromoisatin as the starting material: Mix the alkaline solution of 5-bromoisatin with sodium nitrite solution, add it to dilute sulfuric acid solution under cooling for diazotization, the resulting diazonium salt solution is saturated with sulfur dioxide and reduced with stannous chloride to obtain 5-bromoindazole-3-formic acid. It is difficult to remove a large amount of tin-containing impurities in the obtained crude product, which can be refined by repeated recrystallization with glacial acetic acid. the synthesis reaction formula is as follows: fig. 1 5-bromoindazole -3-formic acid synthesis reaction formula |
Last Update：2024-04-09 20:49:11
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