Name | 5-Chloro-1,3,4-thiadiazol-2-amine |
Synonyms | 5-Chloro-1,3,4-thiadiazol-2-amine 5-Chloro-1,3,4-thiadiazol-2-aMine 1,3,4-Thiadiazol-2-amine, 5-chloro- 5-Chloro-1,3,4-thiadiazol-2-ylamine |
CAS | 37566-40-8 |
Molecular Formula | C2H2ClN3S |
Molar Mass | 135.58 |
Melting Point | 167-169oC |
Solubility | DMSO (Sparingly), Methanol (Very Slightly) |
Appearance | Solid |
Color | White |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
use | is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes. |
Preparation | In the stirred CC14(10.0mL) solution of 1,3, 4-thiadiazol-2-amine (0.5g,4.95mmol), N-chlorosuccinimide (0.73g,5.45mmol) was added at 25°C to allow the reaction to proceed. Stir at 85°C for 2 hours. The reaction was monitored by TLC. After completion, the reaction mixture was quenched with ice-cold water and the compounds were extracted with a DCM solution 10% methanol. The organic layer was washed with water and brine, dried with sodium sulfate and concentrated under reduced pressure to obtain a crude product. Purification of the compounds by silica gel (100-200 mesh) column chromatography using a hexane solution 20% ethyl acetate, resulting in 5-chloro-1, 3, 4-thiadiazol-2-amine (0.18g,26.94%) as a light brown solid. |