5-Methoxy-3-indolylacetonitrile
5-Methoxy-3-indolylacetonitrile
CAS: 2436-17-1
Molecular Formula: C11H10N2O
5-Methoxy-3-indolylacetonitrile - Names and Identifiers
| Name | 5-Methoxy-3-indolylacetonitrile |
| Synonyms | 5-Methoxyindole-3-acetonitrile 5-METHOXYINDOLE-3-ACETONITRILE 5-METHOXY-3-INDOLYLACETONITRILE 3-(Cyanomethyl)-5-methoxyindole 5-Methoxy-3-indolylacetonitrile 3-(Cyanomethyl)-5-methoxy-1H-indole 5-Methoxy indol - 3 -yl Acetonitrile (5-METHOXY-1H-INDOL-3-YL)ACETONITRILE (5-methoxy-1H-indol-3-yl)acetonitrile 2-(5-Methoxy-1H-indol-3-yl)acetonitrile |
| CAS | 2436-17-1 |
| InChI | InChI=1/C11H10N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4H2,1H3 |
5-Methoxy-3-indolylacetonitrile - Physico-chemical Properties
| Molecular Formula | C11H10N2O |
| Molar Mass | 186.21 |
| Density | 1.224±0.06 g/cm3(Predicted) |
| Melting Point | 65-69 °C (lit.) |
| Boling Point | 175-177 °C(Press: 0.01 Torr) |
| Flash Point | 200.7°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 7.09E-07mmHg at 25°C |
| Appearance | Solid |
| Color | Very Dark Brown |
| pKa | 16.02±0.30(Predicted) |
| Storage Condition | -20°C Freezer |
| Refractive Index | 1.638 |
5-Methoxy-3-indolylacetonitrile - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
5-Methoxy-3-indolylacetonitrile - Introduction
It is an organic compound with the molecular formula C12H10N2O. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White or light yellow crystalline solid.
-Melting point: About 111-113 ℃.
-Solubility: It has good solubility in polar organic solvents (such as ethanol, dimethylformamide).
Use:
-Chemical research: It is an important intermediate for the synthesis of indole alkaloids (such as teridine), and has a wide range of applications in the research of drugs and pesticides.
-Synthesis: It can be used to synthesize biologically active compounds, such as antibiotics, photosensitizers, etc.
Method:
The preparation method can be carried out by the following steps:
1.5-methoxyindole (5-Methoxyindole) and Bromoacetonitrile (bromoacetonitril) react to obtain fluorobromide (bromide).
2. Debromination reaction is carried out with alkali agent such as sodium hydroxide under alkaline conditions to obtain phenol.
Safety Information:
-must be unstable under normal operating conditions and should be stored in an airtight container away from direct sunlight.
-Wear appropriate personal protective equipment, such as safety glasses and gloves, during operation and use.
-Avoid skin and eye contact. If discomfort occurs after contact, rinse immediately with plenty of water and seek medical examination.
Please note that the preparation and use of chemicals should be carried out under the guidance of professionals and follow relevant safety procedures.
Nature:
-Appearance: White or light yellow crystalline solid.
-Melting point: About 111-113 ℃.
-Solubility: It has good solubility in polar organic solvents (such as ethanol, dimethylformamide).
Use:
-Chemical research: It is an important intermediate for the synthesis of indole alkaloids (such as teridine), and has a wide range of applications in the research of drugs and pesticides.
-Synthesis: It can be used to synthesize biologically active compounds, such as antibiotics, photosensitizers, etc.
Method:
The preparation method can be carried out by the following steps:
1.5-methoxyindole (5-Methoxyindole) and Bromoacetonitrile (bromoacetonitril) react to obtain fluorobromide (bromide).
2. Debromination reaction is carried out with alkali agent such as sodium hydroxide under alkaline conditions to obtain phenol.
Safety Information:
-must be unstable under normal operating conditions and should be stored in an airtight container away from direct sunlight.
-Wear appropriate personal protective equipment, such as safety glasses and gloves, during operation and use.
-Avoid skin and eye contact. If discomfort occurs after contact, rinse immediately with plenty of water and seek medical examination.
Please note that the preparation and use of chemicals should be carried out under the guidance of professionals and follow relevant safety procedures.
Last Update：2024-04-09 15:17:56
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CAS: 2436-17-1
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CAS: 2436-17-1
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View History
5-Methoxy-3-indolylacetonitrile
871543-07-6
500789-06-0
1018899-04-1
甲基戊醇
1H-INDOL-4-YLMETHANOL
1088991-73-4
77123-57-0
1-氯嚬呐酮
52550-86-4
871543-07-6
500789-06-0
1018899-04-1
甲基戊醇
1H-INDOL-4-YLMETHANOL
1088991-73-4
77123-57-0
1-氯嚬呐酮
52550-86-4