5-Methoxyflavone
5-Methoxyflavone
CAS: 42079-78-7
Molecular Formula: C16H12O3
5-Methoxyflavone - Names and Identifiers
5-Methoxyflavone - Physico-chemical Properties
| Molecular Formula | C16H12O3 |
| Molar Mass | 252.26 |
| Density | 1,155g/cm |
| Melting Point | 131-133°C |
| Boling Point | 422.5±45.0 °C(Predicted) |
| Appearance | Powder |
| Storage Condition | 2-8℃ |
| Sensitive | It will not decompose under normal conditions, and there is no dangerous reaction |
| Refractive Index | 1,548 |
| MDL | MFCD00016942 |
| In vitro study | 5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. 5-methoxyflavone (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate. 5-Methoxyflavone (5-MF, 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 (DR5) in a time-dependent manner. |
| In vivo study | 5-Methoxyflavone (100, 150 mg/kg, i.p) significantly decreases the latency time to loss of righting reflex. 5-Methoxyflavone (50, 100 and 150 mg/kg, i.p) exhibits a significant and dose-dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, i.p) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, i.p) completely abolishesed the grooming response similar to diazepam treated animals. |
5-Methoxyflavone - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
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