500-05-0
Coumalic acid
CAS: 500-05-0
Molecular Formula: C6H4O4
500-05-0 - Names and Identifiers
500-05-0 - Physico-chemical Properties
| Molecular Formula | C6H4O4 |
| Molar Mass | 140.09 |
| Density | 1.2154 (rough estimate) |
| Melting Point | 203-205 °C (dec.) (lit.) |
| Boling Point | 218 °C/120 mmHg (lit.) |
| Flash Point | 218°C/120mm |
| Water Solubility | Very soluble in water. |
| Solubility | Soluble in water |
| Vapor Presure | 0.000881mmHg at 25°C |
| Appearance | tawny powder |
| Color | White to Light yellow to Light orange |
| Merck | 14,2557 |
| BRN | 119747 |
| pKa | 2.80±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.4434 (estimate) |
| MDL | MFCD00006644 |
500-05-0 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29322090 |
500-05-0 - Reference
| Reference Show more | 1. Zhao Rong, Jiang Jun, Xiao Shichang, et al. Taohong Siwu decoction reverses glucocorticoid-induced osteoporosis in zebrafish model [J]. Chinese Journal of Pharmacy, 2019, 54(02):143-150. 2. Li Yina, Zhou, Ying, Yu, Yuan, Shan, Xiao, Shen, Xu, Yu, Juan, Zhou, Bo. Comparative analysis of different phenolic acids on color stability of Sanhua Li Qing juice during storage [J]. Modern Food Science and Technology 2020 36(07):165-172 16. 3. [IF = 4.24] Qun Yu et al."Antityrosinase and antioxidant activity of aspagus and its inhibition on B16F10 melanoma cells before and after chemical treatment." Food Biosci. 2021 Jun;41:101026 4. [IF = 4.235] Dong Qingying et al."High Oxygen Treatments Enhance the Contents of Phenolic Compound and Ganoderic Acid, and the Antioxidant and DNA Damage Protective Activities of Ganoderma lingzhi Fruiting Body."Front Microbiol. 2019 Oct;0:2363 5. [IF=2.431] Dong Qingying et al."Comparative study on phenolic compounds, triterpenoids, and antioxidant activity of Ganoderma lucidum affected by different drying methods."J Food Meas Charact. 2019 Dec;13(4):3198-3205 |
500-05-0 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| p-coumaric acid | p-coumaric acid is also called "4-hydroxycinnamic acid" and "p-hydroxyphenyl acrylic acid". Molecular formula C9H8O3. Molecular weight 164.16. In p-coumaric acid, trans accounts for the vast majority. Pale yellow needle-like crystals. Melting point 214 ℃ (decomposition). Easily soluble in alcohol and ether, soluble in hot water, slightly soluble in benzene and cold water, insoluble in petroleum ether. Reacts with excess bromine in acetic acid to obtain 2, 3-dibromo-3-(3, 5-dibromo-4-hydroxyphenyl) propionic acid, which decomposes quickly with 10% sulfuric acid to release carbon dioxide, and is co-fused with potassium or sodium to obtain 4-hydroxybenzoic acid, which reacts with fuming nitric acid to obtain picric acid, refluxing with 2mol of methyl iodide and 2mol of potassium hydroxide in methanol or heating in a sealed tube at 140°C to obtain methyl 4-methoxycinnamate. Its alcohol solution reacts with ferric chloride in golden brown. Preparation method: It is obtained by the reaction of 4-hydroxybenzaldehyde with anhydrous sodium acetate and acetic anhydride. application:(1) p-coumaric acid is an important intermediate in the production of expectorant rhododendron. (2) as a chemical reagent. Figure 1 is the structural formula of p-coumaric acid. |
Last Update：2024-04-10 22:40:09
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