505084-59-3
3-Pyridinecarboxylicacid, 2-chloro-5-(trifluoromethyl)-
CAS: 505084-59-3
Molecular Formula: C7H3ClF3NO2
505084-59-3 - Names and Identifiers
505084-59-3 - Physico-chemical Properties
| Molecular Formula | C7H3ClF3NO2 |
| Molar Mass | 225.55 |
| Density | 1.603±0.06 g/cm3(Predicted) |
| Melting Point | 281℃ |
| Boling Point | 301.5±42.0 °C(Predicted) |
| Appearance | Crystalline powder |
| pKa | 1.57±0.25(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| MDL | MFCD08741353 |
505084-59-3 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 2811 |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
| Packing Group | Ⅲ |
505084-59-3 - Introduction
3-Pyridinecarboxylicacid, 2-chloro-5-(trifluoromethyl)-, chemical formula C7H3ClF3NO2, also known as 3-Pyridinecarboxylicacid, 2-chloro-5-(trifluoromethyl)-, is an organic compound.
Nature:
3-Pyridinecarboxylicacid, 2-chloro-5-(trifluoromethyl)-is a colorless crystal or white crystalline powder with a special niacin odor. It is insoluble in water at room temperature, but soluble in organic solvents such as chloroform and methanol. It is decomposable at high temperatures.
Use:
3-Pyridinecarboxylicacid, 2-choro-5-(trifluoromethyl)-is a commonly used organic synthesis intermediate. It is often used in the pharmaceutical industry as an intermediate for the synthesis of drugs, especially antibiotics and pesticides. In addition, it can also be used to prepare dyes, high-efficiency coatings and pesticides.
Preparation Method:
3-Pyridinecarboxyllicacid, 2-choro-5-(trifluoromethyl)-usually synthesized by the following steps:
1. First, dissolve pyridine methanol in thionyl chloride.
2. Next, titanium pentachloride was added to the solution to be fluorinated.
3. Add hydrofluoric acid to convert the resulting product into a trifluoromethyl compound.
4. Finally, the product is reacted with nicotinic acid in thionyl chloride to generate 3-Pyridinecarboxylicacid, 2-chloro-5-(trifluoromethyl)-.
Safety Information:
3-Pyridinecarboxylicacid, 2-choro-5-(trifluoromethyl)-is an organic compound, and it should be noted that safety regulations should be followed during operation. It may be irritating to the eyes, skin and respiratory tract, so wear appropriate protective equipment such as gloves and goggles during operation. In addition, it may also be harmful to the environment, so its discharge into water bodies or soil should be avoided. Care should be taken to avoid ignition and high temperatures during storage and handling.
Nature:
3-Pyridinecarboxylicacid, 2-chloro-5-(trifluoromethyl)-is a colorless crystal or white crystalline powder with a special niacin odor. It is insoluble in water at room temperature, but soluble in organic solvents such as chloroform and methanol. It is decomposable at high temperatures.
Use:
3-Pyridinecarboxylicacid, 2-choro-5-(trifluoromethyl)-is a commonly used organic synthesis intermediate. It is often used in the pharmaceutical industry as an intermediate for the synthesis of drugs, especially antibiotics and pesticides. In addition, it can also be used to prepare dyes, high-efficiency coatings and pesticides.
Preparation Method:
3-Pyridinecarboxyllicacid, 2-choro-5-(trifluoromethyl)-usually synthesized by the following steps:
1. First, dissolve pyridine methanol in thionyl chloride.
2. Next, titanium pentachloride was added to the solution to be fluorinated.
3. Add hydrofluoric acid to convert the resulting product into a trifluoromethyl compound.
4. Finally, the product is reacted with nicotinic acid in thionyl chloride to generate 3-Pyridinecarboxylicacid, 2-chloro-5-(trifluoromethyl)-.
Safety Information:
3-Pyridinecarboxylicacid, 2-choro-5-(trifluoromethyl)-is an organic compound, and it should be noted that safety regulations should be followed during operation. It may be irritating to the eyes, skin and respiratory tract, so wear appropriate protective equipment such as gloves and goggles during operation. In addition, it may also be harmful to the environment, so its discharge into water bodies or soil should be avoided. Care should be taken to avoid ignition and high temperatures during storage and handling.
Last Update：2024-04-09 21:01:54
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