5108-96-3
1-Pyrrolidinecarbodithioic acid, ammoniumsalt
CAS: 5108-96-3
Molecular Formula: C5H9NS2.H3N
5108-96-3 - Names and Identifiers
5108-96-3 - Physico-chemical Properties
| Molecular Formula | C5H9NS2.H3N |
| Molar Mass | 164.3 |
| Density | 1.117 (estimate) |
| Melting Point | 153-155°C(lit.) |
| Boling Point | 329.4°C at 760 mmHg |
| Flash Point | 153°C |
| Water Solubility | 50 g/L (20 ºC) |
| Solubility | Soluble in water, slightly soluble in ethanol. |
| Vapor Presure | 0.000178mmHg at 25°C |
| Appearance | White to white-like crystals |
| Color | White to off-white |
| BRN | 3730472 |
| PH | 6-7 (50g/l, H2O, 20℃) |
| Storage Condition | Store at +2°C to +8°C. |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Hygroscopic |
| Refractive Index | 1.5300 (estimate) |
| MDL | MFCD00012720 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Pretreatment of cells with Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate; 3-1000 μM) dose-dependently attenuate IL-8 production. Furthermore, pyrrolidinedithiocarbamate ammonium (100 μM) suppresses the accumulation of IL-8 mRNA. Pyrrolidinedithiocarbamate ammonium inhibits the activation of NF-κB, because it suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate ammonium decrease IL-8 production by intestinal epithelial cells. |
| In vivo study | The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis. |
5108-96-3 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3 |
| TSCA | Yes |
| HS Code | 29339990 |
5108-96-3 - Introduction
Determination of trivalent chromium by emission spectroscopy. A variety of metal complexing agents. Trace lead in urine. Trace determination of cadmium, cobalt, bismuth and molybdenum. Precipitate arsenic, bismuth, cadmium, cobalt, copper, iron, manganese, nickel, lead, antimony, tin, vanadium, and zinc from acidic solutions. Complexing agent for atomic absorption spectrophotometric analysis. Atomic absorption analysis reagents.
Last Update：2022-10-16 17:25:42
5108-96-3 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | pyrrolidine dithioformate ammonium salt is very useful in biochemical applications including metal chelation. It is used to prevent the induction of nitric oxide synthase. It is also very important to inhibit apoptosis of leukemia HL-60 cells. |
| biological activity | Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidine dithiocarbamate, APDC, PDTC, Pyrrolidine dithiocarbamic acid ammonium salt) is an effective inhibitor of NF-κB, inhibiting phosphorylation of IκB, preventing NF-κB translocation into nucleus and reducing the expression of downstream cytokines. |
| Target | Value |
Last Update：2024-04-10 22:29:15
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View History
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