5189-11-7
malic acid, compound with 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine (1:1)
CAS: 5189-11-7
Molecular Formula: C23H27NO5S
5189-11-7 - Names and Identifiers
| Name | malic acid, compound with 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine (1:1) |
| Synonyms | 225-970-4 sanomtgran Sandomigran PIZOTIFEN MALATE Pizotifan Malate Einecs 225-970-4 Pizotifen malate PIZOTYLINE MALATE sandomygranmalate 4-(9,10-DIHYDRO-1-THIA-BENZO[F]AZULEN-4-YLIDENE)-1-METHYL-PIPERIDINE, COMPOUND WITH 2-HYDROXY-SUCCINIC ACID |
| CAS | 5189-11-7 |
| EINECS | 225-970-4 |
| InChI | InChI=1/C19H21NS.C4H6O5/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18;5-2(4(8)9)1-3(6)7/h2-5,10,13H,6-9,11-12H2,1H3;2,5H,1H2,(H,6,7)(H,8,9) |
5189-11-7 - Physico-chemical Properties
| Molecular Formula | C23H27NO5S |
| Molar Mass | 429.53 |
| Melting Point | 185-186° (dec) |
| Boling Point | 436.7°C at 760 mmHg |
| Flash Point | 217.9°C |
| Solubility | Aqueous Acid (Slightly, Heated), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 7.92E-08mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Stability | Hygroscopic |
| In vitro study | Pizotifen malate (BC-105 malate) is a potent 5-HT 2 receptor antagonist, with a high affinity for 5-HT 1C binding site. Pizotifen is an antidepresent 5-HT 2A receptor antagonist and has the capacity to inhibit serotonin-enhanced ADP-induced platelet aggregation. |
| In vivo study | The weights of the fetuses are significantly reduced by all administered doses of Pipethiadene and Pizotifen malate (BC-105 malate) ; the weights of the placentas are significantly reduced after 0.6 and 1.2 mg/kg Pipethiadene and only after the middle dose of Pizotifen malate. The means of the implantations, live, dead fetuses, resorptions and the occurrence of external, skeletal and visceral anomalies do not differ from the control group. The number of chromosome aberrations in the bone marrow cells of treated mice does not differ significantly from the negative control group. The micronucleus test reveals no elevation in the frequency of micronuclei as compared to the control group. After the two higher doses of both Pipethiadene and Pizotifen maleate, the mitotic indices are lower than in the control group. |
5189-11-7 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
5189-11-7 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.328 ml | 11.641 ml | 23.281 ml |
| 5 mM | 0.466 ml | 2.328 ml | 4.656 ml |
| 10 mM | 0.233 ml | 1.164 ml | 2.328 ml |
| 5 mM | 0.047 ml | 0.233 ml | 0.466 ml |
Last Update：2024-01-02 23:10:35
5189-11-7 - Reference Information
| biological activity | Pizotifen Malate (BC-105) is used to treat frequent migraine. |
| use | this product is an antihistamine drug used to treat migraine |
Last Update：2024-04-10 22:29:15
Supplier List
Featured ProductsSpot supply
Product Name: Pizotifen Malate Visit Supplier Webpage Request for quotationCAS: 5189-11-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Pizotifenmalate Request for quotationCAS: 5189-11-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Pizotifen Malate Visit Supplier Webpage Request for quotationCAS: 5189-11-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Pizotyline malate; BC-105 malate Visit Supplier Webpage Request for quotationCAS: 5189-11-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Pizotifen malate Visit Supplier Webpage Request for quotationCAS: 5189-11-7
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Product Name: malic acid, compound with 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine (1:1) Request for quotation
CAS: 5189-11-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 5189-11-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Pizotifen Malate Visit Supplier Webpage Request for quotation
CAS: 5189-11-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 5189-11-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Pizotifen Malate Visit Supplier Webpage Request for quotationCAS: 5189-11-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Pizotifenmalate Request for quotationCAS: 5189-11-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Pizotifen Malate Visit Supplier Webpage Request for quotationCAS: 5189-11-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Pizotyline malate; BC-105 malate Visit Supplier Webpage Request for quotationCAS: 5189-11-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Pizotifen malate Visit Supplier Webpage Request for quotationCAS: 5189-11-7
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Product Name: malic acid, compound with 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine (1:1) Request for quotation
CAS: 5189-11-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 5189-11-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Pizotifen Malate Visit Supplier Webpage Request for quotation
CAS: 5189-11-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 5189-11-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History