52-67-5
D(-)-Penicillamine
CAS: 52-67-5
Molecular Formula: C5H11NO2S
52-67-5 - Names and Identifiers
| Name | D(-)-Penicillamine |
| Synonyms | H-D-Pen-OH Penicilllamine D-Penicillamine D(-)-Penicillamine D-(-)-Penicillamine N,N-dimethylcysteine 3,3-Dimethyl-D(-)-cysteine D-minus-penicillamine free base 3,3-Dimethyl-D-cysteine~3-Mercapto-D-valine |
| CAS | 52-67-5 |
| EINECS | 200-148-8 |
| InChI | InChI=1/C5H11NO2S/c1-6(2)4(3-9)5(7)8/h4,9H,3H2,1-2H3,(H,7,8) |
| InChIKey | VVNCNSJFMMFHPL-VKHMYHEASA-N |
52-67-5 - Physico-chemical Properties
| Molecular Formula | C5H11NO2S |
| Molar Mass | 149.21 |
| Density | 1.171g/cm3 |
| Melting Point | 212℃ |
| Boling Point | 231.297°C at 760 mmHg |
| Flash Point | 93.686°C |
| Water Solubility | 11.1 g/100 mL (20℃) |
| Vapor Presure | 0.022mmHg at 25°C |
| Appearance | Form Powder, color White to almost white |
| pKa | pKa 7.83±0.01(H2O,t =37±0.05,I=0.15)(Approximate) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.514 |
| MDL | MFCD00064302 |
| Physical and Chemical Properties | Chemical Properties White Fine Grain Powder. Melting point 198.5 ℃. Soluble in water, slightly soluble in ethanol, insoluble in ether or chloroform. It has a special smell and bitter taste. |
| Use | Antidote, used for heavy metal ion poisoning, also used for rheumatoid arthritis and chronic active hepatitis and other immune diseases |
52-67-5 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | YV9425000 |
| HS Code | 29309016 |
| Toxicity | LD50 in rats (mg/kg): >10000 orally, >660 i.p. (Jaffe) |
52-67-5 - Upstream Downstream Industry
52-67-5 - Standard
Authoritative Data Verified Data
This product is D-3-mercaptovaline, calculated as dry product, containing C5H11N02S not less than 95.0%.
Last Update：2024-01-02 23:10:35
52-67-5 - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder.
- This product is soluble in water, slightly soluble in ethanol, insoluble in ether.
specific rotation
take this product, precision weighing, plus lmol/L sodium hydroxide solution dissolved and quantitatively diluted to make a solution containing about 50mg per lml, determined according to law (General 0621), the specific rotation is from one to 61.0 ° to one to 65.0 °.
Last Update：2022-01-01 13:33:05
52-67-5 - Differential diagnosis
Authoritative Data Verified Data
- take about 40mg of this product, add 4ml of water to dissolve, add 2ml of Phosphotungstic acid solution (1-10), shake, place for several minutes, and the solution shows dark blue.
- take this product and penicillamine reference, respectively, dissolved in water and diluted to make a solution containing about 0502 mg per 1 ml, according to thin layer chromatography (general) test, draw 2ul of each of the above two solutions, respectively, on the same silica gel G thin layer plate, with n-butanol-glacial acetic acid-water (72:18:18) as the developing agent, dry at 105 ° C. For 10 minutes, place the iodine vapor in the cylinder for 5-10 minutes, the position and color of the main spot displayed by the test solution should be the same as the position and color of the main spot displayed by the reference solution.
- take about 0.5mg of this product, add 0.5ml of hydrochloric acid and 4ml of acetone to warm and dissolve, cool in an ice bath, rub the tube wall with a glass rod to precipitate white precipitate, filter, the precipitate was washed with acetone, dried in air, and the precipitate was prepared into a 1% aqueous solution, which should be dextrorotatory.
Last Update：2022-01-01 13:33:06
52-67-5 - Exam
Authoritative Data Verified Data
acidity
take this product, add water to make a solution containing 10 mg per lml, according to the law (General 0631), the pH value should be 4.0~6.0.
penicillamine disulfide
take about 0.125g of this product, weigh it accurately, put it in a 100ml measuring flask, and add diluent (take ethylenediamine tetraacetic acid disodium l.Og, add water to dissolve and dilute into 1000ml, shake well) dissolve and dilute to the scale, shake well, as a test solution; additionally, an appropriate amount of penicillamine disulfide reference substance dried at 105°C to constant weight was precisely weighed, dissolved and quantitatively diluted with the above diluent to prepare a solution containing about 12.5ug per 1 ml as the reference solution; take appropriate amounts of penicillamine control and penicillamine disulfide control, and add the above diluent to dissolve and dilute to prepare penicillamine 1 mg and penicillamine disulfide per 1 ml. A solution of 1 mg was used as the system suitability solution. According to the determination by high performance liquid chromatography (General rule 0512), silica gel was bonded with eighteen alkyl silane as filler; Sodium hexanesulfonate phosphate solution [take sodium dihydrogen phosphate 0.2g and sodium hexanesulfonate g, add water to dissolve, adjust the pH value to 3.0±0.1 with phosphoric acid solution (1-10), dilute to 1000ml with water, mix well] as mobile phase; The detection wavelength is 210mn, take the system applicable solution 20u1 and inject it into human liquid chromatograph, record the chromatogram, the resolution between penicillamine peak and penicillamine disulfide peak should be greater than 3.0. The sample solution and the reference solution were respectively injected with 20ul, and the chromatogram was recorded. Calculated by peak area according to external standard method, containing penicillamine disulfide shall not exceed 1.0%.
penicillin
- determined according to microbiological assay for antibiotics (General rule 1201).
- preparation of culture medium 6.0g of peptone, 4.0g of trypsin-digested casein, 3.0g of yeast extract powder, 1.5g of beef extract powder, and l of glucose. g, 15.0g of Agar, 6.5 of water, the pH value was adjusted to 6.7 to 115 after sterilization, and the mixture was sterilized at ° C. For 30 minutes.
- The Test fungus Micrococcus luteus, Micrococcus luteus [CMCC(B)28001], the bacteria liquid was prepared.
- preparation of control solution an appropriate amount of a penicillin control was accurately weighed, dissolved in a sterile phosphate buffer (pH 6.0) and quantitatively diluted to prepare a solution containing 0.02 units per 1 ml.
- preparation of test solution lg of this product was accurately weighed and placed in a separatory funnel, 9ml of water was added to dissolve, 10ml of diethyl ether and 1 ml of phosphate buffer (pH 2.5) were added, the mixture was extracted by shaking for 1 min. The aqueous layer was separated into another separatory funnel and extracted twice with ether, 10ml each time. The ether layer was combined, and 9ml of water and 1 ml of phosphate buffer (pH 2.5) were added, shake for 30 seconds, discard the water layer (the above operation should be completed in 6~7 minutes). The ether layer was extracted with 10ml of sterile phosphate buffer (pH 6.0) for 3 minutes, 5ml of the aqueous layer was taken as the test solution (1), and 0 was added to the remaining aqueous layer. 1 ml of penicillinase (more than 3 million units per 1 ml of penicillinase) was left at 36-37°C for 1 hour as a test solution (2).
- no less than 4 pieces of double-dish shall be used for the measurement. 10ml of medium shall be added to the middle and bottom layers of each dish, 5ml of medium shall be added to the bacteria layer, and 6 pieces of stainless steel tubules shall be placed in each dish, the control solution, the test solution (1) and the test solution (2) were respectively dropped in two diagonal tubes, and cultured at 29 to 30 ° C. For 24 hours, the diameter of each zone of inhibition was measured. The average diameter of the bacteriostatic circle caused by the test solution (1) shall not be greater than the average diameter of the bacteriostatic circle caused by the reference solution. Do not produce inhibition zone (0.2 units/g).
loss on drying
take this product, with phosphorus pentoxide as desiccant, at 60°C under reduced pressure drying to constant weight, weight loss should not exceed 0.5% (General rule 0831).
Last Update：2022-01-01 13:33:07
52-67-5 - Content determination
Authoritative Data Verified Data
take this product about 0.15g, precision weighing, add acetate buffer (take sodium acetate 5.4g, put 100ml measuring flask, add water 50ml to dissolve, adjust pH value to 4.6 with glacial acetic acid, add water to dilute to the scale, Shake) 100ml to dissolve and dilute to the scale, according to the potentiometric titration method (General 0701), with platinum electrode as the indicator electrode, Mercury-sulfuric acid mercury electrode as the reference electrode, slowly titrate to the end point with mercury nitrate titration solution (0.05mol/L). Each 1 ml of mercury nitrate titration solution (0.05mol/L) is equivalent to 7.461mg of C5H11NO2S.
Last Update：2022-01-01 13:33:08
52-67-5 - Category
Authoritative Data Verified Data
Heavy metal antidote.
Last Update：2022-01-01 13:33:08
52-67-5 - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 13:33:08
52-67-5 - Penicillamine tablets
Authoritative Data Verified Data
This product contains penicillamine (C5H11N02S) should be 90.0% to 110.0% of the label.
trait
This product is sugar-coated tablets, White after removing the coating.
identification
take this product, remove the coating, grind, weigh an appropriate amount (about 0.25g equivalent to penicillamine), add 25ml of water, stir to dissolve, filter, the filtrate showed the same results according to the tests of (1) and (2) under the item of penicillamine.
examination
- penicillamine disulfide take 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 0.125g equivalent to penicillamine), put it in a 200ml measuring flask, add an appropriate amount of diluent (ethylene diamine tetraacetic acid disodium 1.og, dissolved in water and diluted to make 1000ml, shake well), shake for 5 minutes to dissolve penicillamine, and let stand for 90 minutes, shake well, filter, and take the continued filtrate as the test solution. In addition, take an appropriate amount of penicillamine disulfide reference substance dried at 105°C to constant weight, weigh it precisely, dissolve and quantitatively dilute it with the above diluent to prepare a solution containing about 18.75ug per 1 ml, which is used as the reference solution, penicillamine-containing disulfides shall not exceed 3.0% of the labeled amount as determined by the method described under penicillamine.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 10 tablets of this product, precision weighing, fine grinding, precision weighing to take an appropriate amount (about 0.15g equivalent to penicillamine), according to the method of penicillamine under the item, then get.
category
Same as penicillamine.
specification
0.125g
storage
sealed storage.
Last Update：2022-01-01 13:33:09
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View History
Raw Materials for 52-67-5
Potassium benzylpenicillin
Phenylhydrazine
Mercury chloride
Hydrogen Sulfide
4-Thiazolidinecarboxylic acid, 5,5-dimethyl-2-[[(2-phenylacetyl)amino]methyl]-, (2R,4S)-
Phenylhydrazine
Mercury chloride
Hydrogen Sulfide
4-Thiazolidinecarboxylic acid, 5,5-dimethyl-2-[[(2-phenylacetyl)amino]methyl]-, (2R,4S)-
Downstream Products for 52-67-5