527-95-7
Herbacetin
CAS: 527-95-7
Molecular Formula: C15H10O7
527-95-7 - Names and Identifiers
527-95-7 - Physico-chemical Properties
| Molecular Formula | C15H10O7 |
| Molar Mass | 302.24 |
| Density | 1.799 |
| Melting Point | 284℃ |
| Boling Point | 618.7±55.0 °C(Predicted) |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents. |
| Appearance | Yellow powder |
| pKa | 6.49±0.40(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD00210585 |
| Physical and Chemical Properties | It is soluble in organic solvents such as methanol, ethanol, DMSO, and comes from the ground part of Equisetum and Rhodiola. |
| In vivo study | Herbacetin (orally administration; 20mg/kg) significantly reduces the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant mice (OIR). (Herbacetin dissolves in 0.5% DMSO). Herbacetin (intraperitoneal injection; 0.4, 2, 10 or 20 mg/kg; B.W.) decreases the number and size of polyps in APCM in+ mice with no overt toxicity. |
527-95-7 - Reference
| Reference Show more | 1. Zhao Liangzi, GE Beikang, et al. Determination of six active components in Rhodiola extract by UPLC-MS/MS [J]. International Journal of Pharmaceutical Research 2016 43(005):975-979. 2. [IF = 16.806] Shujing Zhang et al.Discovery of Herbacetin as a Novel SGK1 Inhibitor to alloy. Advanced Science.2021 Nov 10 3. [IF = 6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure-Activity Relationship, Kinetics and Interaction Mechanism." Frontal in Nutrition. 2022; 9: 892426 |
527-95-7 - Reference Information
| overview | grass quality (herbacetin) is 3,4 ',5,7,8-pentahydroxy substituted flavonoids, mainly found in pen container grass, Rhodiola rosea, cotton and other plants. At present, there are few studies on the biological activity and pharmacological activity of grass at home and abroad. However, the research shows that the position and number of phenolic hydroxyl functional groups play an important role in antioxidant activity. In view of the structure of grass containing 5 phenolic hydroxyl groups, it is speculated that it may have strong antioxidant activity in vitro. Herbopyrin can effectively eliminate DPPH radicals and hydroxyl radicals and inhibit protein oxidation, and its antioxidant activity is stronger than the corresponding glycosides. At the same time, studies have shown that the pharmacological activity of the 7-position hydroxyl group of the ring in the grass quality structure will decrease after saccharification, and the more sugar, the lower the activity; the antioxidant activity of flavonoids increases with the number of phenolic hydroxyl groups in the molecule, and the activity increases. In addition, oxalin can induce apoptosis of human hepatoma cell HepG2, which has the potential to develop a new anticancer preparation. |
| Preparation | The method for extracting grass quality from Rhodiola rosea includes the following steps; 1) The crushed Rhodiola rosea medicinal materials are extracted with an extraction solvent, and the extract is concentrated under reduced pressure to obtain the extract extract extract; 2) The extract extract extract, and the extracted water layer is subjected to acid hydrolysis; 3) The acid-hydrolyzed solution is extracted with an organic solvent, the extract is combined, and the herbaceous extract is concentrated under reduced pressure to obtain the herbaceous extract; 4) The herbaceous extract is treated by polyamide column chromatography, The stream containing grass quality is collected and concentrated to dry to obtain crude grass quality; 5) The crude grass quality is treated by reversed-phase silica gel column chromatography, collect the streams containing grass quality, concentrate to dry, and recrystallize to obtain pure grass quality. |
| biological activity | Herbacetin are natural flavonoids in flaxseed and have various pharmacological activities, including antioxidant, anti-inflammatory and anti-cancer effects. Grass protamine is an allosteric inhibitor of ornithine decarboxylase Ornithine decarboxylase (ODC), which directly binds to Asp44,Asp243 and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis. |
| target | IC50: Ornithine decarboxylase |
| in vivo study | Herbacetin (orally administration; 20 mg/kg) significantly reduces the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant (OIR). (Herbacetin dissolves in 0.5% DMSO). Herbacetin (intraperitoneal injection; 0.4, 2,10 or 20 mg/kg; B. w.) decreases the number and size of polyps in APCM in + mice with no overt toxicity. |
| Chemical properties | Soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the ground part of Equisetum and Rhodiola. |
| use | used for content determination/identification/pharmacological experiments, etc. |
Last Update：2024-04-09 19:05:04
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