537050-14-9

537050-14-9 - Names and Identifiers

Name	2-Bromo-1-[4-fluoro-3-(trifluoromethyl)phenyl]ethanone
Synonyms	4-Fluoro-3-(Trifluoromethyl)phenacylbromide 4-FLUORO-3-(TRIFLUOROMETHYL)PHENACYL BROMID 2-bromo-1-(4-fluoro-3-(trifluoromethyl)phenyl)ethanone 2-Bromo-1-[4-fluoro-3-(trifluoromethyl)phenyl]ethanone 1-[4-fluoro-3-(trifluoroMethyl)phenyl]ethan-1-one broMide ethanone, 2-bromo-1-[4-fluoro-3-(trifluoromethyl)phenyl]- Ethanone, 2-bromo-1-[4-fluoro-3-(trifluoromethyl)phenyl]- 2-bromo-1-(4-fluoro-3-(trifluoromethyl)phenyl)ethan-1-one 2-Bromo-4'-fluoro-3'-(trifluoromethyl)acetophenone, 2-Bromo-1-[4-fluoro-3-(trifluoromethyl)phenyl]ethan-1-one
CAS	537050-14-9
EINECS	689-991-4
InChI	InChI=1/C9H5BrF4O/c10-4-8(15)5-1-2-7(11)6(3-5)9(12,13)14/h1-3H,4H2

537050-14-9 - Physico-chemical Properties

Molecular Formula	C9H5BrF4O
Molar Mass	285.03
Density	1.658
Melting Point	42-44
Boling Point	250℃
Flash Point	105℃
Vapor Presure	0.0225mmHg at 25°C
Storage Condition	Inert atmosphere,2-8°C
Sensitive	Lachrymatory
Refractive Index	1.481
MDL	MFCD03094509

537050-14-9 - Risk and Safety

Risk Codes	22 - Harmful if swallowed
UN IDs	3261
Hazard Note	Corrosive/Lachrymatory/Keep Cold
Hazard Class	KEEP COLD, LACHRYMAT
Packing Group	III

537050-14-9 - Introduction

2-Bromo-1-[4-fluoro-3-(trifluoromethyl)phenyl]ethanone, the chemical formula is C10H6BrF4O. The following is a description of its nature, use, formulation and safety information:

Nature:
1. Appearance: Colorless to light yellow crystal or solid.
2. Molecular weight: 307.05g/mol.
3. melting point: 48-51 ℃.
4. Boiling point: 239-240 ℃.
5. Solubility: Soluble in organic solvents such as chloroform, methanol and dichloromethane.

Use:
2-Bromo-1-[4-fluoro-3-(trifluoromethyl)phenyl]ethanone have a variety of uses in organic synthesis, including:
1. as a chemical synthesis intermediate, used in the synthesis of drugs and pesticides and other organic compounds.
2. As a reducing reagent, carboxylic acid derivatives can be converted into corresponding alcohols.
3. As an important chemical reagent for the carbonylation reaction in organic synthesis.

Preparation Method:
2-Bromo-1-[4-fluoro-3-(trifluoromethyl)phenyl]ethanone can be synthesized by the following steps:
1. first, hydrobromic acid and acetone are added to the reaction system to generate 2-acetone bromo.
2. add 2-acetonyl bromide and silver tetrafluoroacetate together into the reaction system to react to generate 4-acetonyl bromide.
3. finally, 3-chloromethyl-4-fluorobenzoic acid methyl ester and trifluoromethanesulfonyl chloride are added into the reaction system, and the target product 2-Bromo-1-[4-fluoro-3-(trifluoromethyl)phenyl]ethanone is generated under the catalysis of a base.

Safety Information:
1. The toxicity and biological activity of this compound have not been comprehensively studied, so it needs to be handled with caution.
2. During operation and storage, personal protective equipment such as protective gloves, protective glasses and chemical protective clothing should be worn.
3. avoid inhalation of its vapor, avoid contact with skin and eyes.
4. in case of accidental contact, rinse immediately with plenty of water and seek medical help if necessary.
5. Store under appropriate conditions, away from fire and oxidant.

Last Update：2024-04-09 21:00:56