5573-16-0
SAIKOGENIN D
CAS: 5573-16-0
Molecular Formula: C30H48O4
5573-16-0 - Names and Identifiers
5573-16-0 - Physico-chemical Properties
| Molecular Formula | C30H48O4 |
| Molar Mass | 472.7 |
| Density | 1.16±0.1 g/cm3(Predicted) |
| Melting Point | 261-266 °C |
| Boling Point | 607.4±55.0 °C(Predicted) |
| Appearance | Powder |
| pKa | 14.47±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca 2+ ionophore A23187 in a concentration-dependent manner with an IC 50 value of 3 μM in C6 rat glioma cells. Saikogenin D (10-100 μM) elevates [Ca 2+ ]i in a concentration-dependent manner with a EC 50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells. |
5573-16-0 - Reference Information
| biological activity | Saikogenin d is isolated from Bupleurum chinense and has anti-inflammatory effect. Saikogenin D activates cyclooxygenase, converting arachidonic acid to epoxyeicosanoic acid and dihydroxyeicosatrienoic acid, whose metabolites in turn inhibit the production of prostaglandin E2 (PGE2). Saikogenin D leads to an increase in [Ca2 +] I due to intracellular Ca2 + release. |
| in vitro study | Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca 2 ionophore A23187 in a concentration-dependent manner with an IC 50 value of 3 μM in C6 rat glioma cells. Saikogenin D (10-100 μM) elevates [Ca 2] I in a concentration-dependent manner with a EC 50 value of 35 μM in presence or absence of extracellular Ca2 in C6 rat glioma cells. |
Last Update：2024-04-09 21:11:58
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