5578-73-4
SANGUINARINE CHLORIDE
CAS: 5578-73-4
Molecular Formula: C20H14ClNO4
5578-73-4 - Names and Identifiers
5578-73-4 - Physico-chemical Properties
| Molecular Formula | C20H14ClNO4 |
| Molar Mass | 367.78 |
| Melting Point | 281-285°C |
| Water Solubility | methanol: 20 mg/mL, clear, orange |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | Shape Orange solid. color Orange to Dark Orange |
| Storage Condition | Inert atmosphere,2-8°C |
| Stability | Hygroscopic, Light Sensitive |
| MDL | MFCD00012126 |
| Physical and Chemical Properties | Chemical properties Red needle-like crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., are derived from Bo Luobi. |
| Use | Sanguinarine (Sanguinarin) chloride is an alkaloid derived from Sanguinaria Canadensis that stimulates apoptosis by activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is related to the activation of JNK and NF-κB. |
5578-73-4 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | VP5220000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29399990 |
5578-73-4 - Upstream Downstream Industry
5578-73-4 - Introduction
Slightly soluble in water (<0.3 mg/mL), soluble in methanol (3.8 mg/mL)
Last Update：2022-10-16 17:30:59
5578-73-4 - Nature
| Solubility | methanol: 20 mg/mL, clear, orange |
Last Update：2024-04-10 22:29:15
5578-73-4 - Uses and synthesis methods
biological activity
Sanguinarine (Sanguinarin) chloride is an alkaloid derived from Sanguinaria Canadensis, which can stimulate cell apoptosis by activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is related to JNK and NF-& kappa; Activation of B.
Target
Target Value
PP2C
(Cell-free) 0.68 μM(Ki)
in vitro studies
Sanguinarine (SANG)-induced apoptosis is associated with the activation of JNK and NF-κ B signal pathways.To determine the effects of Sanguinarine on cell viability, 22B-cFluc cells are stimulated with different concentrations of Sanguinarine for 24 h, and then a CKK-8 assay is performed. The treatment with Sanguinarine decreases the proliferation of 22B cells in a dose-dependent manner. Meanwhile, the cytosolic extracts of 22B-cFluc cells treated with different dose of Sanguinarine are measured to detect cellular caspase-3 activity using Ac-DEVD-pNA, which is a validated caspase-3 substrate. The absorbance at 450 nm increases in a dose-dependent manner, indicating increased caspase-3 activity stimulated by Sanguinarine.
In vivo studies
To evaluate the apoptosis induced by Sanguinarine (SANG) in vivo, 22B-cFluc cells are inoculated subcutaneously into one flank of nude mice and xenograft models are allowed to establish. Mice are treated intravenously with 10 mg/kg of Sanguinarine. At 24, 48 and 72 h after treatment, bioluminescent imaging is performed after I .p. injection of mice with 150 mg/kg of D-luciferin substrate. Sanguinarine treatment induces an obvious increase of luminescent signal as early as 48 h after initial treatment. A sustained bioluminescent imaging (BLI) intensity increased is observed throughout the course of experiment. At 72 h after treatment, the tumors are collected and subjected to TUNEL staining for evaluating apoptosis. Compared with the control tumors, the group treated with Sanguinarine exhibits significantly more cell apoptosis, indicated by the increased green signals from the sporadic apoptotic cells.
Use
A natural product with antibacterial, anti-inflammatory and antioxidant properties. It can inhibit the expansion of tumor cell lines and promote apoptosis.
Last Update：2024-04-09 22:09:11
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Mobile: +86-18821248368
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Product Name: Sanguinarine chloride Request for quotationCAS: 5578-73-4
Tel: 400-968-2212
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Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
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Product Name: Sanguinarine chloride Visit Supplier Webpage Request for quotationCAS: 5578-73-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
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Multiple SpecificationsSpot supply
Product Name: Sanguinarine chloride Visit Supplier Webpage Request for quotationCAS: 5578-73-4
Tel: 609-228-6898
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tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: SANGUINARINE CHLORIDE Visit Supplier Webpage Request for quotationCAS: 5578-73-4
Tel: +86 0571-86722205
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QQ: 2531159185
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