56538-57-9
2-([(Benzyloxy)Carbonyl]Amino)-2-Hydroxyacetic Acid
CAS: 56538-57-9
Molecular Formula: C10H11NO5
56538-57-9 - Names and Identifiers
| Name | 2-([(Benzyloxy)Carbonyl]Amino)-2-Hydroxyacetic Acid |
| Synonyms | N-CBZ-ALPHA-HYDROXYGLYCINE CBZ-D,L-ALPHA-HYDROXYGLYCINE N-Carbobenzoxy-2-hydroxyglycine ALPHA-HYDROXY-N-(BENZYLOXYCARBONYL) GLYCINE [[(Benzyloxy)carbonyl]amino](hydroxy)acetic acid 2-([(Benzyloxy)Carbonyl]Amino)-2-Hydroxyacetic Acid 2-([(BENZYLOXY)CARBONYL]AMINO)-2-HYDROXYACETIC ACID 2-Hydroxy-2-[[(phenylmethoxy)carbonyl]amino]acetic acid Acetic acid, 2-hydroxy-2-[[(phenylmethoxy)carbonyl]amino]- |
| CAS | 56538-57-9 |
| InChI | InChI=1/C10H11NO5/c12-8(9(13)14)11-10(15)16-6-7-4-2-1-3-5-7/h1-5,8,12H,6H2,(H,11,15)(H,13,14)/t8-/m0/s1 |
| InChIKey | JQEZLSUFDXSIEK-UHFFFAOYSA-N |
56538-57-9 - Physico-chemical Properties
| Molecular Formula | C10H11NO5 |
| Molar Mass | 225.2 |
| Density | 1.406 |
| Melting Point | 120-121℃ |
| Boling Point | 470.3±45.0 °C(Predicted) |
| Appearance | White powder |
| pKa | 3.33±0.11(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.582 |
| MDL | MFCD02179279 |
56538-57-9 - Introduction
2-([(Benzyloxy)Carbonyl]Amino)-2-Hydroxyacetic Acid is an organic compound with the chemical formula C10H11NO5. It is an amide derivative of benzyloxy and hydroxyglycine with functional groups of anisole and glycolic acid.
The properties of the compound are as follows:
-Appearance: White or off-white solid
-Melting point: about 126-128°C
-Solubility: Soluble in water and some organic solvents, such as methanol and ethanol
2-([(Benzyloxy)Carbonyl]Amino)-2-Hydroxyacetic Acid is mainly used in chemical synthesis and biological research, and has the following applications:
-As a protecting group in organic synthesis, hydroxyl or amino functional groups can be protected to selectively carry out chemical modification in the reaction.
-In the synthesis of peptides and proteins, it can be used as an intermediate or protective group for synthesis reactions.
-In drug research, it can be used as a tool to control the pharmacokinetic properties and synthesis methods of drugs.
The preparation method of 2-([(Benzyloxy)Carbonyl]Amino)-2-Hydroxyacetic Acid usually includes the following steps:
1. React glycolic acid with tert-butoxycarbonyl-glycylyl chloride to obtain tert-butoxycarbonyl-hydroxyglycine.
2. Tert-butoxycarbonyl-hydroxyglycine is reacted with sodium benzyl bromide to generate 2-([(Benzyloxy)Carbonyl]Amino)-2-Hydroxyacetic Acid.
Regarding the safety information of 2-([(Benzyloxy)Carbonyl]Amino)-2-Hydroxyacetic Acid, no relevant toxicological and safety data have been publicly reported. When handling and using the compound, it is recommended to follow laboratory safety operating procedures and take necessary protective measures, such as wearing gloves, laboratory work clothes and safety glasses. For more specific safety information, it is recommended to refer to the relevant safety data sheet for the chemical or consult a professional.
The properties of the compound are as follows:
-Appearance: White or off-white solid
-Melting point: about 126-128°C
-Solubility: Soluble in water and some organic solvents, such as methanol and ethanol
2-([(Benzyloxy)Carbonyl]Amino)-2-Hydroxyacetic Acid is mainly used in chemical synthesis and biological research, and has the following applications:
-As a protecting group in organic synthesis, hydroxyl or amino functional groups can be protected to selectively carry out chemical modification in the reaction.
-In the synthesis of peptides and proteins, it can be used as an intermediate or protective group for synthesis reactions.
-In drug research, it can be used as a tool to control the pharmacokinetic properties and synthesis methods of drugs.
The preparation method of 2-([(Benzyloxy)Carbonyl]Amino)-2-Hydroxyacetic Acid usually includes the following steps:
1. React glycolic acid with tert-butoxycarbonyl-glycylyl chloride to obtain tert-butoxycarbonyl-hydroxyglycine.
2. Tert-butoxycarbonyl-hydroxyglycine is reacted with sodium benzyl bromide to generate 2-([(Benzyloxy)Carbonyl]Amino)-2-Hydroxyacetic Acid.
Regarding the safety information of 2-([(Benzyloxy)Carbonyl]Amino)-2-Hydroxyacetic Acid, no relevant toxicological and safety data have been publicly reported. When handling and using the compound, it is recommended to follow laboratory safety operating procedures and take necessary protective measures, such as wearing gloves, laboratory work clothes and safety glasses. For more specific safety information, it is recommended to refer to the relevant safety data sheet for the chemical or consult a professional.
Last Update：2024-04-09 21:54:55
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