5853-29-2
Cephaeline hydrochloride
CAS: 5853-29-2
Molecular Formula: C28H39ClN2O4
5853-29-2 - Names and Identifiers
5853-29-2 - Physico-chemical Properties
| Molecular Formula | C28H39ClN2O4 |
| Molar Mass | 503.08 |
| Appearance | neat |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | White to yellow powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ipecac, angola octagonal maple. |
| In vitro study | CYP2D6 reveals the highest metabolic activity for the generation of 9-O-demethylEmetine, whereas this enzyme also shows a significant metabolic activity for the generation of Cephaeline. The IC 50 s of Cephaeline against CYP2C9, CYP2D6 and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (K i ) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield K i s of 54 and 355 μM for CYP2D6 and CYP3A4, respectively. |
5853-29-2 - Risk and Safety
| UN IDs | 1544 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in mouse: 74970ug/kg |
5853-29-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.853 ml | 9.267 ml | 18.534 ml |
| 5 mM | 0.371 ml | 1.853 ml | 3.707 ml |
| 10 mM | 0.185 ml | 0.927 ml | 1.853 ml |
| 5 mM | 0.037 ml | 0.185 ml | 0.371 ml |
Last Update：2024-01-02 23:10:35
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CAS: 5853-29-2
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