58569-55-4
H-TYR-GLY-GLY-PHE-MET-OH
CAS: 58569-55-4
Molecular Formula: C27H35N5O7S
58569-55-4 - Names and Identifiers
58569-55-4 - Physico-chemical Properties
| Molecular Formula | C27H35N5O7S |
| Molar Mass | 573.66 |
| Density | 1.324±0.06 g/cm3(Predicted) |
| Melting Point | 174-177 °C |
| Boling Point | 1052.9±65.0 °C(Predicted) |
| Appearance | Form powder, color white |
| pKa | 3.23±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Physical and Chemical Properties | Chemical properties of white or white powder, composed of 5 amino acids, the order is L-tyrosine, glycine, L-phenylalanine, L-methionine. |
| Use | Uses for biochemical research, neurobiological research. |
58569-55-4 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10-21 |
58569-55-4 - Upstream Downstream Industry
| Raw Materials | Glycine L-Phenylalanine L-Tyrosine L-Methionine |
| Downstream Products | 4-HYDROXY-3-NITROBENZYL ALCOHOL |
58569-55-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.743 ml | 8.716 ml | 17.432 ml |
| 5 mM | 0.349 ml | 1.743 ml | 3.486 ml |
| 10 mM | 0.174 ml | 0.872 ml | 1.743 ml |
| 5 mM | 0.035 ml | 0.174 ml | 0.349 ml |
Last Update：2024-01-02 23:10:35
58569-55-4 - Nature
| specific rotation | 31.5°(D/25℃)(c=0.96,メタノール) |
Last Update：2024-04-10 22:29:15
58569-55-4 - Uses and synthesis methods
biological activity
Tyr-Gly-Gly-Phe-Met-OH can regulate human immune function and inhibit tumor growth by binding to opioid receptor.
target
Opioid Receptor.
in vitro study
Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems.
production method
using L-tyrosine, glycine, L-phenylalanine and L-methionine as raw materials, the side chains of amino acids with side chains in amino acids are protected by protective agents according to their characteristics, then condensation reaction is carried out in the presence of polypeptide condensing agent, and then the protective agent is removed and purified.
Last Update：2024-04-10 22:29:15
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Tel: 609-228-6898
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Raw Materials for 58569-55-4
Downstream Products for 58569-55-4