5909-24-0
ethyl 4-chloro-2-methylthio-5-pyrimidine-carboxyl
CAS: 5909-24-0
Molecular Formula: C8H9ClN2O2S
5909-24-0 - Names and Identifiers
5909-24-0 - Physico-chemical Properties
| Molecular Formula | C8H9ClN2O2S |
| Molar Mass | 232.69 |
| Density | 1.37±0.1 g/cm3(Predicted) |
| Melting Point | 60-63 °C (lit.) |
| Boling Point | 132°C/0.4mmHg(lit.) |
| Flash Point | 156.83°C |
| Solubility | Chloroform, Ethyl Acetate |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Off White to Light Yellow Solid |
| Color | White to light yellow to beige |
| pKa | -2.19±0.29(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.568 |
| MDL | MFCD00006085 |
5909-24-0 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Note | Irritant |
| Hazard Class | IRRITANT, KEEP COLD |
5909-24-0 - Reference Information
| Application | 4-chloro-2-methylthiopyrimidine-5-carboxylic acid ethyl ester is an intermediate in organic synthesis and a pharmaceutical intermediate, it is mainly used for the synthesis of non-important intermediates of Avalone. Avanafil is an orally available, highly selective Phosphodiesterase-5 (PDE-5) inhibitor for the treatment of erectile dysfunction in men. ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate is used as an intermediate in organic synthesis and a pharmaceutical intermediate in laboratory research and development and in chemical and pharmaceutical synthesis. |
| preparation | ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate is a white solid in shape, usually by ethoxymethylene malonate Diethyl ester and S-methylisothiourea sulfate in ethanol-sodium ethoxide solution reaction, concentrated to remove ethanol, adjust the pH to acidic, the intermediate 4-hydroxy-2-methylthiopyrimidine-5-carboxylic acid ethyl ester was obtained; the obtained ethyl 4-hydroxy-2-methylthiopyrimidine-5-carboxylate was reacted with phosphorus oxychloride to obtain the target product |
Last Update：2024-04-09 19:05:13
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