5909-24-0

5909-24-0 - Names and Identifiers

Name	ethyl 4-chloro-2-methylthio-5-pyrimidine-carboxyl
Synonyms	SIEHE AV22429 4-chloro-2-methylthio-5-pyrimidnecarboxylat 2-METHYLTHIO-4-CHLORO-5-ETHOXYCARBONYLPYRIMIDINE 4-chloro-5-ethoxycarbonyl-2-methylthiopyrimidine ethyl 4-chloro-2-methylthio-5-pyrimidine-carboxyl Ethyl 4-Chloro2-methylthiopyrimidine-5-carboxylate Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate ETHYL 4-CHLORO-2-METHYLTHIO-5-PYRIMIDINECARBOXYLATE ETHYL 4-CHLORO-2-METHYLTHIOPYRIMIDINE-5-CARBOXYLATE Ethyl-4-chloro-2-(methylthio)pyrimidine-5-carboxylate Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate ethyl 4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylate ETHYL 4-CHLORO-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE 4-Chloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester
CAS	5909-24-0
EINECS	227-619-0
InChI	InChI=1/C8H9ClN2O2S/c1-3-13-7(12)5-4-10-8(14-2)11-6(5)9/h4H,3H2,1-2H3
InChIKey	SNNHLSHDDGJVDM-UHFFFAOYSA-N

5909-24-0 - Physico-chemical Properties

Molecular Formula	C8H9ClN2O2S
Molar Mass	232.69
Density	1.37±0.1 g/cm3(Predicted)
Melting Point	60-63 °C (lit.)
Boling Point	132°C/0.4mmHg(lit.)
Flash Point	156.83°C
Solubility	Chloroform, Ethyl Acetate
Vapor Presure	0mmHg at 25°C
Appearance	Off White to Light Yellow Solid
Color	White to light yellow to beige
pKa	-2.19±0.29(Predicted)
Storage Condition	2-8°C
Refractive Index	1.568
MDL	MFCD00006085

5909-24-0 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
HS Code	29339900
Hazard Note	Irritant
Hazard Class	IRRITANT, KEEP COLD

5909-24-0 - Reference Information

Application

4-chloro-2-methylthiopyrimidine-5-carboxylic acid ethyl ester is an intermediate in organic synthesis and a pharmaceutical intermediate, it is mainly used for the synthesis of non-important intermediates of Avalone. Avanafil is an orally available, highly selective Phosphodiesterase-5 (PDE-5) inhibitor for the treatment of erectile dysfunction in men.
ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate is used as an intermediate in organic synthesis and a pharmaceutical intermediate in laboratory research and development and in chemical and pharmaceutical synthesis.

preparation

ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate is a white solid in shape, usually by ethoxymethylene malonate Diethyl ester and S-methylisothiourea sulfate in ethanol-sodium ethoxide solution reaction, concentrated to remove ethanol, adjust the pH to acidic, the intermediate 4-hydroxy-2-methylthiopyrimidine-5-carboxylic acid ethyl ester was obtained; the obtained ethyl 4-hydroxy-2-methylthiopyrimidine-5-carboxylate was reacted with phosphorus oxychloride to obtain the target product

Last Update：2024-04-09 19:05:13

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View History

5909-24-0
67774-74-7
104-90-5
111-25-1
2497-21-4
134640-85-0
340041-91-0
3054-95-3
Iso Amyl Isovalerate
BUTYL VALERIANATE

5909-24-0

ethyl 4-chloro-2-methylthio-5-pyrimidine-carboxyl

CAS: 5909-24-0

Molecular Formula: C8H9ClN2O2S

5909-24-0 - Names and Identifiers

5909-24-0 - Physico-chemical Properties

5909-24-0 - Risk and Safety

5909-24-0 - Reference Information

Supplier List

5909-24-0 Request for Quotation

ethyl 4-chloro-2-methylthio-5-pyrimidine-carboxyl

CAS: 5909-24-0

Molecular Formula: C8H9ClN2O2S

5909-24-0 - Names and Identifiers

5909-24-0 - Physico-chemical Properties

5909-24-0 - Risk and Safety

5909-24-0 - Reference Information

Supplier List

5909-24-0