59461-30-2
Hydroxocobalamin monohydrochloride
CAS: 59461-30-2
Molecular Formula: C62H89ClCoN13O15P
59461-30-2 - Names and Identifiers
59461-30-2 - Physico-chemical Properties
| Molecular Formula | C62H89ClCoN13O15P |
| Molar Mass | 1381.83 |
| Solubility | methanol: soluble10mg/mL at 20°C, clear, dark red |
| Appearance | neat |
| Storage Condition | 2-8°C |
| Use | Hydroxo balamin monohydrozolide (Vitamin B12a monohydrozolide) is an injectable natural Vitamin B12 with good adverse reaction characteristics, which can be used |
| In vitro study | The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide and hydroxocobalamin attenuates vascular responses to NO in vitro . |
| In vivo study | Treatment with hydroxocobalamin before or after giving LPS attenuates LPS-induced hypotension and increases in plasma RNI and enhances LPS-induced urinary excretion of RNI. Hydroxocobalamin (20 mg/kg i.p.) given to Swiss-Webster mice 30 min before giving LPS (16 mg/kg i.p.) decreases the 24-hr mortality of LPS from 80 to 50% and the 36- and 96-hr mortality from 100 to 60% (hydroxocobalamin). More than 60% of the mice administered 35 mg/kg (0.63 mmol/kg) of NaSH (LD90) survive (at 24 h) when hydroxocobalamin (0.25 mmol/kg) is given after NaSH administration whereas less than 15% of the mice survive without hydroxocobalamin. Hydroxocobalamin (50–100 μM) or cobalt (50–100 μM) also preventes hepatocyte cytotoxicity induced by NaSH (500 μM). Furthermore, adding hydroxocobalamin 60 min later than NaSH still shows some protective activity. |
59461-30-2 - Risk and Safety
| WGK Germany | 3 |
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Product Name: Hydroxocobalamin hydrochloride Request for quotationCAS: 59461-30-2
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Multiple SpecificationsSpot supply
Product Name: Hydroxocobalamin (monohydrochloride) (Standard) Visit Supplier Webpage Request for quotationCAS: 59461-30-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
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Mobile: 609-228-6898
Multiple SpecificationsSpot supply
Product Name: Hydroxocobalamin hydrochloride Visit Supplier Webpage Request for quotationCAS: 59461-30-2
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