5995-86-8
Gallic acid monohydrate
CAS: 5995-86-8
Molecular Formula: C7H8O6
5995-86-8 - Names and Identifiers
| Name | Gallic acid monohydrate |
| Synonyms | Gallic Acid, Hydrate GALLIC ACID, HYDRATE GALLIC ACID-1-HYDRATE Gallic Acid-1-Hydrate GALLIC ACID MONOHYDRATE Gallic acid monohydrate 3,4,5-Trihydroxybenzoate Gallic Acid(Monohydrate) 3,4,5-Trihydroxybenzoic Acid Hydrate Gallic Acid, Monohydrate, Crystal, Reagent, ACS |
| CAS | 5995-86-8 |
| EINECS | 611-919-7 |
| InChI | InChI=1/C7H6O5.H2O/c8-4-1-3(7(11)12)2-5(9)6(4)10;/h1-2,8-10H,(H,11,12);1H2 |
| InChIKey | IUTKPPDDLYYMBE-UHFFFAOYSA-N |
5995-86-8 - Physico-chemical Properties
| Molecular Formula | C7H8O6 |
| Molar Mass | 188.13 |
| Density | 1.694 |
| Melting Point | 252°C (dec.)(lit.) |
| Boling Point | 596.6°C at 760 mmHg |
| Flash Point | 250°C |
| Water Solubility | 15 g/l (20 ºC) |
| Solubility | Soluble in hot water, alcohol glycerin and acetone, slightly soluble in ether, insoluble in benzene, chloroform and petroleum ether. |
| Vapor Presure | 4.43E-15mmHg at 25°C |
| Appearance | grayish white to beige powder |
| Color | White to cream |
| Merck | 14,4345 |
| BRN | 2050274 |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Stability | Light Sensitive |
| Sensitive | Hygroscopic |
| MDL | MFCD00149098 |
| Physical and Chemical Properties | White or yellowish needle-like crystals, or prismatic crystals. It has silk luster and slightly sour taste. Soluble in ethanol, acetone, ethylene glycol, slightly soluble in water, ether. |
| In vitro study | Gallic acid is an antioxidant which can inhibit both COX-2. After 18 h treatment with Gallic acid, the number of viable neutrophils is dramatically decreased from 40.3% to 27.7%, highly comparable with 26.4% for untreated neutrophils. Gallic acid fails to attenuate isoproterenol-induced myocytolysis. |
| In vivo study | The food intake (2.6±0.08 g/day, p=0.69) and the body weight (2.5±0.69 g, p=0.76) of the Gallic acid group do not differ significantly from those of the control group (food intake; 2.41±0.14 g/day and the body weight; 2.83±0.84 g/day). The blood glucose tolerance in the Gallic acid group is significantly improved after 2 weeks of treatment. The blood glucose tolerance of the Gallic acid group after a treatment period of 2 weeks is also significantly better than that of the control group at 90 and 120 min ( p<0.05). The serum triglyceride concentration in the Gallic acid group (0.67±0.03 mM, p<0.05) is significantly reduced relative to that of the control group (1.08±0.20 mM). The total cholesterol concentration is similar in the control (3.19±0.27 mM) and Gallic acid (3.01±0.18 mM) groups. |
5995-86-8 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | LW7525000 |
| FLUKA BRAND F CODES | 8-9-23 |
| TSCA | Yes |
| HS Code | 29182900 |
5995-86-8 - Reference
| Reference Show more | 1. [IF=4.952] Jiayue Gao et al."Reduction of oil uptake in deep-fried apple slices by the combined ultrasonic and ethanol pre-treatment."Lwt Food Sci Technol. 2021 Dec;152:112274 2. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 |
5995-86-8 - Nature
Open Data Verified Data
in the form of tannins in Galla Chinensis, mistletoe bark and tea. White or yellowish needle-like crystals, or prismatic crystals. It has silk luster, slightly sour taste and astringency. Water of crystallization was lost at 100 N120 °c. Soluble in ethanol, acetone, ethylene glycol, water-soluble, ether. The relative density was 1. 694. Melting point 251 °c (decomposition).
Last Update：2025-06-10 22:55:16
5995-86-8 - Preparation Method
Open Data Verified Data
The Gallic Tannin was hydrolyzed under pressure to give gallic acid, which was further hydrolyzed to gallic acid and glucose. Reaction temperature 133~135 ℃, pressure 0. 1765~0.19 61MPA.
Last Update：2022-01-01 10:43:11
5995-86-8 - Introduction
No smell, slightly sour, turning brown when exposed to light. Heat to 100-120 ℃ and lose crystal water. There is convergence. Soluble in hot water, alcohol glycerin and acetone, slightly soluble in ether, insoluble in benzene, chloroform and petroleum ether. 1g dissolved in 87ml of water, 3ml of boiling water, 6ml of ethanol, 100ml of ether, 10ml of glycerin and 5ml of acetone. Half lethal dose (rabbit, oral) 5g/kg. It's irritating.
Last Update：2022-10-16 17:26:53
5995-86-8 - Application
Open Data Verified Data
pyrogallic acid, drugs, inks, media dyes can be prepared. Detection of free inorganic acid, two hydroxy acetone and alkaloids. It can also be used as a developer and as a food preservative for preparation of propyl gallate. Anti-explosion agents can also be prepared and used as analytical chemical reagents.
Last Update：2025-08-19 16:24:40
5995-86-8 - Safety
Open Data Verified Data
- This product is slightly irritating, although it can produce methemosin to warm-blooded animals, but the toxicity is mild, the human body takes 2~4g daily, and does not show any symptoms of poisoning. Rats were injected subcutaneously with LD 4000mg/kg and frog LD 2000mg/kg.
- industrial grade products are packed in plastic bags, 50kg per bag. Reagent grade products are packed in plastic bags, each bag 500g, packed in wooden boxes, each box 40 bags, net weight 20kg. Storage and transportation should pay attention to moisture, mildew, oxidation deterioration. Reagent grade products should be sealed and protected from light.
Last Update：2022-01-01 10:43:12
5995-86-8 - Reference Information
| Biological activity | Gallic acid (3,4, 5-Trihydroxybenzene acid) hydrate is a natural polyhydroxyphenolic compound that inhibits cyclooxygenase-2 (COX-2) Free radical scavenging effect. Gallic acid hydrate has a variety of activities, such as antibacterial, antioxidant, antibacterial, anti-inflammatory and anti-tumor activities. |
| target | COX-2 Human Endogenous Metabolite |
| in vitro study | Gallic acid is an antioxidant which can inhibit both COX-2. after 18 h treatment with Gallic acid, the number of viable neutrophils is dramatically decreased from 40.3% to 27.7%, highly comparable with 26.4% for untreated neutrophils. Gallic acid fail to attenuate isoproterenol-induced myocytolysis. |
| in vivo study | The food intake (2.6±0.08g/day, p = 0.69) and the body weight (2.5±0.69g, P = 0.76) of the Gallic acid group do not differ significantly from those of the control group (food intake; 2.41±0.14g/day and the body weight; 2.83±0.84g/day). The blood glucose tolerance in the Gallic acid group is significantly improved after 2 weeks of treatment. The blood glucose tolerance of the Gallic acid group after a treatment period of 2 weeks is also significantly better than that of the control group at 90 and 120 min ( p<0.05). The serum triglyceride concentration in the Gallic acid group (0.67±0.03 mM, P <0.05) is significantly reduced relative to that of the control group (1.08±0.20 mM). The total cholesterol concentration is similar in the control (3.19±0.27 mM) and Gallic acid (3.01±0.18 mM) groups. |
| chemical properties | white or light yellow needle crystals, or prismatic crystals. It has silk luster and slightly sour taste. Soluble in ethanol, acetone, ethylene glycol, slightly soluble in water, ether. |
| use | used in the manufacture of thiazide dyes, oxazine dyes, drugs, etc. used as a depolarization agent in electrochemical analysis; used to reduce phosphomolybdic acid; used to verify antimony, barium, bismuth, calcium, cerium and copper, etc; used for the determination of phosphorus, nitrite, silver, thorium and titanium, etc. test free mineral acid, dihydroxyacetone and alkaloids, etc., depolarization agent in electro-chemical analysis, reduction of phosphomolybdic acid, and verification of antimony, Barium, bismuth, calcium, cerium and copper, etc. Determination of phosphorus, nitrite, silver, thorium and titanium. |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | vein-mouse LD50: 320 mg/kg |
| flammability hazard characteristics | flammable, spicy and irritating smoke |
| storage and transportation characteristics | warehouse low temperature, ventilation, drying |
| extinguishing agent | water, carbon dioxide, dry powder, sand |
Last Update：2024-04-09 20:49:11
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View History
5995-86-8
3762-25-2
20126-59-4
106498-32-2
169749-99-9
78-67-1
948014-34-4
11078-31-2
122-01-0
HYDROXYTYROSOL 羟基酪醇
3762-25-2
20126-59-4
106498-32-2
169749-99-9
78-67-1
948014-34-4
11078-31-2
122-01-0
HYDROXYTYROSOL 羟基酪醇