6-Chloro-5-fluoroindole
6-Chloro-5-fluoroindole
CAS: 122509-72-2
Molecular Formula: C8H5ClFN
6-Chloro-5-fluoroindole - Names and Identifiers
| Name | 6-Chloro-5-fluoroindole |
| Synonyms | 6-CHLORO-5-FLUOROINDOLE 6-Chloro-5-fluoroindole - 6-chloro-5-fluroindole 6-Chloro-5-fluoro-1H-indole 6-chloro-5-fluoro-1H-indole 1H-Indole,6-chloro-5-fluoro- 6-Chloro-5-fluoroindole fandachem |
| CAS | 122509-72-2 |
| EINECS | 640-181-9 |
| InChI | InChI=1/C7H10F2O2/c8-7(9)3-1-5(2-4-7)6(10)11/h5H,1-4H2,(H,10,11) |
6-Chloro-5-fluoroindole - Physico-chemical Properties
| Molecular Formula | C8H5ClFN |
| Molar Mass | 169.58 |
| Density | 1.436±0.06 g/cm3(Predicted) |
| Melting Point | 105-107°C |
| Boling Point | 299.8±20.0 °C(Predicted) |
| Flash Point | 99.6°C |
| Vapor Presure | 0.0122mmHg at 25°C |
| pKa | 15.26±0.30(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.432 |
| Physical and Chemical Properties | Light yellow solid |
6-Chloro-5-fluoroindole - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Note | Irritant |
6-Chloro-5-fluoroindole - Introduction
6-Chloro-5-fluoroindole is an organic compound with the formula C8H4ClFN. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: 6-Chloro-5-fluoroindole is white crystal or crystalline powder.
-Melting point: about 75-77 degrees Celsius.
-Solubility: Soluble in common organic solvents, such as ethanol and dimethyl sulfoxide.
Use:
-6-Chloro-5-fluoroindole is widely used in the pharmaceutical field. As an active indole compound, it can be used in the synthesis of anti-tumor drugs, antiviral drugs and so on.
-It can also be used as a catalyst or intermediate in organic synthesis.
Preparation Method:
6-chloro-5-fluoroindole is prepared by a variety of methods, and common methods include the following:
-Reaction of 5-fluoroindole with chlorous acid to obtain 5-chloroindole. It is then reacted with chlorous acid chloride to give 6-chloro-5-chloroindole. Finally, 6-chloro-5-chloroindole is fluorinated to give 6-chloro-5-fluoroindole.
-Use the synthesis reaction of indole to introduce 6-chloro and 5-fluoro groups during the synthesis process.
Safety Information:
Detailed safety information on 6-chloro-5-fluoroindole is currently lacking, so caution is required when using this compound. Wear appropriate protective equipment such as lab gloves and goggles during operation. Avoid contact with skin and eyes. In case of inhalation or contact, the affected area should be cleaned in time. Detailed safety operation guidelines should be formulated according to the specific situation and use environment. Prior to the use of new compounds, it is recommended that the necessary toxicological evaluation be carried out.
Nature:
-Appearance: 6-Chloro-5-fluoroindole is white crystal or crystalline powder.
-Melting point: about 75-77 degrees Celsius.
-Solubility: Soluble in common organic solvents, such as ethanol and dimethyl sulfoxide.
Use:
-6-Chloro-5-fluoroindole is widely used in the pharmaceutical field. As an active indole compound, it can be used in the synthesis of anti-tumor drugs, antiviral drugs and so on.
-It can also be used as a catalyst or intermediate in organic synthesis.
Preparation Method:
6-chloro-5-fluoroindole is prepared by a variety of methods, and common methods include the following:
-Reaction of 5-fluoroindole with chlorous acid to obtain 5-chloroindole. It is then reacted with chlorous acid chloride to give 6-chloro-5-chloroindole. Finally, 6-chloro-5-chloroindole is fluorinated to give 6-chloro-5-fluoroindole.
-Use the synthesis reaction of indole to introduce 6-chloro and 5-fluoro groups during the synthesis process.
Safety Information:
Detailed safety information on 6-chloro-5-fluoroindole is currently lacking, so caution is required when using this compound. Wear appropriate protective equipment such as lab gloves and goggles during operation. Avoid contact with skin and eyes. In case of inhalation or contact, the affected area should be cleaned in time. Detailed safety operation guidelines should be formulated according to the specific situation and use environment. Prior to the use of new compounds, it is recommended that the necessary toxicological evaluation be carried out.
Last Update：2024-04-09 21:54:55
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