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60314-89-8

Geissoschizine methyl ether

CAS: 60314-89-8

Molecular Formula: C22H26N2O3

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60314-89-8 - Names and Identifiers

Name Geissoschizine methyl ether
Synonyms geissoschizine methylether
Geissoschizine methyl ether
(16E,19E)-16,17,19,20-Tetradehydro-17-methoxycorynan-16-carboxylic acid methyl ester
(Z)-methyl 2-((2S,12bS,E)-3-ethylidene-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate
Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethylidene-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-, methyl ester, (αZ,2S,3E,12bS)-
CAS 60314-89-8

60314-89-8 - Physico-chemical Properties

Molecular FormulaC22H26N2O3
Molar Mass366.45
Density1.23±0.1 g/cm3(Predicted)
Boling Point542.0±50.0 °C(Predicted)
Solubility Soluble in methanol, DMSO, chloroform, acid water
AppearanceWhite powder or crystal
pKa18.02±0.40(Predicted)
Storage ConditionSealed in dry,Store in freezer, under -20°C
SensitiveAvoid light
MDLMFCD30725476
Physical and Chemical PropertiesWhite crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Uncaria.

60314-89-8 - Reference

Reference
Show more
1. [IF=4.759] Keyu Feng et al."Configuration of the ion exchange chromatography, hydrophilic interaction chromatography, and reversed-phase chromatography as off-line three-dimensional chromatography coupled with high-resolution quadrupole-Orbitrap mass spectrometry fo
2. [IF=6.529] Lingling Xie et al."Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway."Biomed Pharmacother. 2022 Feb;146:112607

60314-89-8 - Reference Information

Overview Uncaria is a plant of the genus Uncaria (Uncaria) in the Rubiaceae (Rubiaceae), and the main active ingredient is alkaloids, such as rhynchophylline (rhynchophylline), Isorchophylline (isorhynchophylline), etc. Uncaria is a commonly used medicine in traditional Chinese medicine, which has the effects of clearing heat and calliding the liver, relieving wind and setting alarm, and lowering blood pressure.
biological activity Geissoschizine methyl ether, an alkaloid compound found Uncaria hook, is also the main active ingredient of Yokukansan with psychotropic drugs. Geissoschizine methyl ether is an agonist of the potent 5-HT1A receptor.
target 5-HT 1A Receptor
chemical properties white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from uncaria.
use rhynchophylline has anti-platelet aggregation, anti-thrombosis and blood pressure lowering effects.
used for content determination/identification/pharmacological experiment, etc.
Last Update:2024-04-10 22:29:15
60314-89-8
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