6078-17-7
BERBAMINE DIHYDROCHLORIDE
CAS: 6078-17-7
Molecular Formula: C37H40N2O6·2HCl
6078-17-7 - Names and Identifiers
| Name | BERBAMINE DIHYDROCHLORIDE |
| Synonyms | BERBENINE BERBAMINE HCL BERBAMINE 2HCL Magnolia officinalis P.E. BERBAMINE DIHYDROCHLORIDE 6,6,7-Trimethoxy-2,2-dimethylberbaman-12-ol dihydrochloride |
| CAS | 6078-17-7 |
6078-17-7 - Physico-chemical Properties
| Molecular Formula | C37H40N2O6·2HCl |
| Molar Mass | 681.65 |
| Melting Point | 250-253 °C(lit.) |
| Boling Point | 744.4°C at 760 mmHg |
| Solubility | Slightly soluble in cold water, easily soluble in boiling water, almost insoluble in cold ethanol, chloroform, ether |
| Appearance | Yellow white or light yellow |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Avoid light |
| MDL | MFCD11982910 |
| Physical and Chemical Properties | Chemical properties of white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Coptis root, Berberis root (three needles). |
| Use | Uses Berbamine hydrochloride has the effects of enhancing immunity, anti-tuberculosis, dilating blood vessels, anti-myocardial hypoxia and ischemia. |
6078-17-7 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
6078-17-7 - Reference
| Reference Show more | 1. Hou Xuezhi, Zhang Zhenqiu, you Chunxue, etc. Determination of 11 components in extracts of Coptis chinensis and Scutellaria baicalensis Georgi by HPLC [J]. Journal of Pharmaceutical Analysis 2013(1):57-62. 2. Wang, Asia. Simultaneous determination of chlorogenic acid, polydatin and berberine hydrochloride in scald mixture by HPLC [J]. Chinese pharmacist 2012(07):993-995. 3. Yan Qi, Li Li, Juanjuan, et al. Simultaneous determination of seven components in the root of altissima nigricans by HPLC [J]. Chinese herbal medicine, 42 Vol. 7, 2020-1588 p. M. 4. Chen Cheng, Luo Guoping, Feng suamin, Zhang chunlao, Yan Mengru, Guo Yanru. Optimization of extraction process of Pueraria lobata-Coptis chinensis medicinal pair based on PB design and response surface methodology of fabd [J]. China pharmacist, 2018,21(02):228-231. 5. Li Yajie, long Lan, Yang Yongkang, etc. Study on quality standard of Rhizoma coptidis in Enshi [J]. Journal of Hubei University for Nationalities: Natural Science Edition, 2012, 000(004):443-445. 6. Huo, Xiaowei, et al. "Aqueous extract of Cordyceps sinensis potentiates the antitumor effect of DDP and attenuates therapy-associated toxicity in non-small cell lung cancer via IκBα/NFκB and AKT/MMP2/MMP9 pathways." Rsc Advances 7.60 (2017): 37743-37754.ht 7. [IF=3.119] Xiaowei Huo et al."Aqueous extract of Cordyceps sinensis potentiates the antitumor effect of DDP and attenuates therapy-associated toxicity in non-small cell lung cancer via IκBα/NFκB and AKT/MMP2/MMP9 pathways."Rsc Adv. 2017 Jul;7(60):37743-37754 8. [IF=4.432] Liufang Yin et al."Berbamine reduces body weight via suppression of small GTPase Rab8a activity and activation of paraventricular hypothalamic neurons in obese mice."Eur J Pharmacol. 2022 Feb;916:174679 |
6078-17-7 - Nature
| optical activity (optical activity) | [α]20/D +116°, c = 1% in ethanol |
Last Update：2024-04-10 22:40:09
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View History
6078-17-7
330858-28-1
1005196-61-1
122-31-6
19789-60-7
51933-78-9
铬酸酐
Diethyl chlorophosphite
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330858-28-1
1005196-61-1
122-31-6
19789-60-7
51933-78-9
铬酸酐
Diethyl chlorophosphite
446-52-6
富马酸GS-7340