61-80-3
2-Amino-5-chlorobenzoxazole
CAS: 61-80-3
Molecular Formula: C7H5ClN2O
61-80-3 - Names and Identifiers
| Name | 2-Amino-5-chlorobenzoxazole |
| Synonyms | Zoxine Zoxamin usafma-12 Zoxazolamine ZOXAZOLAMINE TIMTEC-BB SBB003874 2-Amino-5-chlorobenzoxazole 2-AMINO-5-CHLOROBENZOXAZOLE 5-chlorobenzoxazol-2-ylamine 5-chloro-1,3-benzoxazol-2-amine 2-Amino-5-chlorobenzoxazoleZoxazolamine |
| CAS | 61-80-3 |
| EINECS | 200-519-4 |
| InChI | InChI=1/C7H5ClN2O/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3H,(H2,9,10) |
61-80-3 - Physico-chemical Properties
| Molecular Formula | C7H5ClN2O |
| Molar Mass | 168.58 |
| Density | 1.4369 (rough estimate) |
| Melting Point | 181-184°C(lit.) |
| Boling Point | 316.8±34.0 °C(Predicted) |
| Flash Point | 145.4°C |
| Solubility | DMSO, Methanol |
| Vapor Presure | 0.000401mmHg at 25°C |
| Appearance | Powder |
| Color | Light brown to yellow-brown |
| Merck | 13,10249 |
| pKa | 0.73±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.5618 (estimate) |
| In vitro study | Zoxazolamin is a class of central muscle relaxant drugs that have been reported to act by reducing the activity between central neurons. These drugs, but not the anti-Anxiety drugs, reduce dopamine conversion and induce pacemaker-like firing patterns at dopaminergic neurons. Zoxazolamin belongs to the class of 2-amino -2-oxazoles with biological activity. Zoxazolamin has also been used as a tool to assess hepatocyte cytochrome P-450 activity. |
| In vivo study | Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents. The time-averaged serum clearance determined from tested concentrations data is 7.22±1.01 mL/min/kg for Zoxazolamine. Infusion of Zoxazolamine to righting reflex (LRR) at three different rates shows increasing Zoxazolamine concentration in serum and brain at the onset of the effect with increasing infusion rates. When the Zoxazolamine infusion is continued for 5 min beyond the onset of LRR, the concentrations of Zoxazolamine in the cerebrospinal fluid (CSF) at the offset of LRR are essentially identical to the onset concentrations. |
61-80-3 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | DM4550000 |
| HS Code | 29349990 |
| Toxicity | LD50 in mice, rats (mg/kg): 376, 102 i.p.; 678, 730 orally (Cain, Roszkowski) |
61-80-3 - Reference Information
| biological activity | Zoxazolamine (NSC 24995, Contrazole) is a central muscle relaxant used as an antispasmodic and uric acid-promoting drug. |
| in vitro study | zoxazolamin is a class of central muscle relaxant drugs that have been reported to act by reducing activity between central neurons. These drugs, but not the anti-Anxiety drugs, reduce dopamine conversion and induce pacemaker-like firing patterns at dopaminergic neurons. Zoxazolamin belongs to the class of 2-amino -2-oxazoles with biological activity. Zoxazolamin has also been used as a tool to assess hepatocyte cytochrome P-450 activity. |
| in vivo studies | Zoxazolamine is widely used for a pharmacologic test that serves as a convention indicator of changes in cyanochrome P-450 activity in robots. The time-averaged serum clearance determined from tested concentrations data is 7.22±1.01/min/kg for Zoxazolamine. Infusion of Zoxazolamine to right reflex (LRR) at three different rates shows increasing Zoxazolamine concentration in serum and brain at the onset of the effect with increasing infusion rates. When the Zoxazolamine infusion is continued for 5 min beyond the onset of LRR, the concentrations of Zoxazolamine in the cerebrospinal fluid (CSF) at the offset of LRR are essentially identical to the onset concentrations. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50:782 mg/kg; Oral-mouse LD50:540 mg/kg |
| flammability hazard characteristics | flammability; Toxic NOx and chloride fumes from combustion |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
Last Update：2024-04-10 22:29:15
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