61276-17-3
acteoside
CAS: 61276-17-3
Molecular Formula: C29H36O15
61276-17-3 - Names and Identifiers
61276-17-3 - Physico-chemical Properties
| Molecular Formula | C29H36O15 |
| Molar Mass | 624.59 |
| Density | 1.60±0.1 g/cm3(Predicted) |
| Melting Point | 232℃ |
| Boling Point | 908.8±65.0 °C(Predicted) |
| Specific Rotation(α) | (c, 1.15 in MeOH)-84.9 |
| Flash Point | 294.7°C |
| Solubility | Soluble in ethanol, methanol, ethyl acetate, insoluble in petroleum ether. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White needle crystal |
| Color | White to Pale Yellow |
| pKa | 9.31±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Hygroscopic |
| Refractive Index | 1.689 |
| MDL | MFCD00221751 |
| Physical and Chemical Properties | White-like or light yellow crystalline powder, soluble in methanol, derived from Dayun (hard Cistanche deserticola with the highest blackening content 0.47%). |
| In vitro study | Verbascoside acts as an ATP-competitive inhibitor of PKC, with an IC 50 of 25 µM. Verbascoside shows K i s of 22 and 28 µM with respect to ATP and histone, respectively. Verbascoside has potent antitumor activity against L-1210 cells, with an IC 50 of 13 µM. Verbascoside (5, 10 µM) suppresses 2,4-dinitrochlorobenzene (DNCB)-induced T cell costimulatory factors CD86 and CD54, proinflammatory cytokines, and NFκB pathway activation in THP-1 cells. |
| In vivo study | Verbascoside (1%) reduces the overall scratching behavior incidence as well as the severity of the skin lesions in 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) mice model. Verbascoside also blocks DNCB-induced expression of proinflammatory cytokine TNF-α, IL-6, and IL-4 mRNA in skin lesions. Verbascoside (50, 100 mg/kg, i.p.) does not modify chronic constriction injury (CCI)-induced cold allodynia. Verbascoside (200 mg/kg, i.p.) decreases hyper-sensitivity to cold stimulus, acetone, on day 3 in rats. Verbascoside also significantly reduces behavioral changes associated with neuropathy. Moreover, Verbascoside decreases Bax and increases Bcl-2 on day 3. |
61276-17-3 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | LZ5786000 |
| HS Code | 29389090 |
| Toxicity | LD50 oral in rat: > 5gm/kg |
61276-17-3 - Reference Information
| overview | ergosterol is an oxygen glycoside in glycosides, also known as mullein and mullein. It is relatively stable under acidic conditions. The stability is poor under neutral and alkaline conditions, but the addition of appropriate amount of ascorbic acid can obviously inhibit its degradation. Mainly exist in some medicinal plants, such as Cistanche plants, Forsythia plants, Rehmannia plants and Ledang plants. Ergosterin has strong biological activity and various effects. It has the effects of anti-aging, improving immune function, enhancing memory, relieving pain, lowering blood lipids and laxative. |
| preparation | extraction method of ergosterol from osmanthus fragrans, comprising the following steps: S1. Grind sweet osmanthus into powder; S2. Extraction with cable extractor; S3. The crude extract of Osmanthus fragrans obtained in step S2 is extracted and concentrated, preferably, the crude extract of Osmanthus fragrans is extracted and concentrated with petroleum ether, ethyl acetate, and water-saturated n-butanol; S5. Rotating at 40°C and then lyophilizing to obtain ergosterol. HPLC determination of concentrated sweet-scented osmanthus crude extract: preparation of sweet-scented osmanthus crude extract solution: accurately weigh 2mg of sweet-scented osmanthus crude extract, place it in a 25mL volumetric flask, add appropriate amount of methanol to dissolve and fix the volume, filter through a 0.45 μm filter membrane, and sweet-scented osmanthus crude extract solution solution. |
| biological activity | Verbascoside are glycosides obtained from Lantana camara, which are ATP competitive PKC inhibitors with an IC50 value of 25 µM and have anti-tumor, anti-inflammatory, anti-neuropathic pain and other effects. |
| target | PKC 25 μM (IC 50 ) |
| in vitro research | Verbascoside acts as an ATP-competitive inhibitor of PKC, with an IC 50 of 25 m. Verbascoside shows K I s of 22 and 28 m with respect to ATP and histone, respectively. Verbascoside has potent antitumor activity against L-1210 cells, with an IC 50 of 13 m. Verbascoside (5, 10 m) suppresses 2,4-dinitrochlorobenzene (DNCB)-induced T cell costimulatory factors CD86 and CD54, proinflammatory cytokines, and NFκB pathway activation in THP-1 cells. |
| in vivo research | Verbascoside (1%) reduces the overall scratching behavior incidence as well as the severity of the skin lesions in 2, 4-dinitrolorobenzene (DNCB)-induced atopic dermatitis (AD) mice model. Verbascoside also blocks DNCB-induced expression of proinflammatory cytokine TNF-α, IL-6, and IL-4 mRNA in skin lesions. Verbascoside (50, 100 mg/kg, I. p.) does not modify chronic constriction (CCI)-induced cold allodynia. Verbascoside (200 mg/kg, I. p.) decreases hyper-sensitivity to cold stimulus, acetone, on day 3 in rats. Verbascoside also significantly reduces behavioral changes associated with neuropathy. Moreover, Verbascoside decreases Bax and increases Bcl-2 on day 3. |
| chemical properties | white or light yellow crystalline powder, soluble in methanol, it is derived from Dayun (the highest 0.47% of black content of hard Cistanche deserticola). |
| use | mullein glycoside has anti-inflammatory, immune enhancement, anti-hypoxia and anti-cancer effects. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It has the pharmacological effects of regulating immunity, anti-oxidation, enhancing physical strength, anti-fatigue, etc. |
Last Update：2024-04-09 20:49:11
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