| Name | ent-Tadalafil |
| Synonyms | ent-Tadalafil (S,S)-Tadalafil Tadanafil EP or USP impurity B Tadalafil Impurity B (ent-tadalafil) Tadalafil EP Impurity B ((6S,12S)-Tadalafil) |
| CAS | 629652-72-8 |
| Molecular Formula | C22H19N3O4 |
| Molar Mass | 389.4 |
| Density | 1.51±0.1 g/cm3(Predicted) |
| Melting Point | 278-282°C |
| Boling Point | 679.1±55.0 °C(Predicted) |
| Solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| Appearance | Solid |
| Color | White |
| pKa | 16.68±0.40(Predicted) |
| Storage Condition | -20°C Freezer |
| biological activity | ent-Tadalafil (ent-IC-351), compound (6S,12aS), is the inactive cis-enantiomer of compound (6R,12aS). The compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while the ent-Tadalafil remains inactive at a high concentration of 10 µM. |
| target | PDE5 10 μM (IC 50 ) |