633283-53-1

633283-53-1 - Names and Identifiers

Name	tert-Butyl 4-(6-chloropyridin-3-yl)piperazine-1-carboxylate
Synonyms	tert-Butyl 4-(6-chloropyridin-3-yl)piperazine-1-carboxylate 4-(6-Chloro-pyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester 1-Piperazinecarboxylic acid, 4-(6-chloro-3-pyridinyl)-, 1,1-dimethylethylester
CAS	633283-53-1

633283-53-1 - Physico-chemical Properties

Molecular Formula	C14H20ClN3O2
Molar Mass	298
Storage Condition	2-8℃

633283-53-1 - Risk and Safety

Hazard Class

IRRITANT

633283-53-1 - Upstream Downstream Industry

Raw Materials

4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINE
5-Bromo-2-chloropyridine
tert-Butyl 1-piperazinecarboxylate

633283-53-1 - Introduction

1,1-Dimethylethyl 4-(6-chloro-3-pyridyl)-1-piperazinecarboxylate is an organic compound containing a piperazine ring and a chloropyridyl group in its structure. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: White solid
-Molecular formula: C14H20ClN3O2
-Molecular weight: 299.78g/mol
-Melting point: about 88-90 degrees Celsius
-Solubility: Soluble in organic solvents such as dichloromethane and dimethyl sulfoxide
-Odor: Has a special odor

Use:
4-(6-chloro-3-pyridine)-1-piperazine carboxylic acid 1,1-dimethyl ethyl ester has a wide range of applications in the pharmaceutical field, mainly used as intermediates or raw materials:
-for the synthesis of biologically active compounds or drugs
-as a synthetic intermediate for antipsychotic drugs
-Drug research for inhibition of cholinergic receptors

Method:
The method for synthesizing 1,1-dimethylethyl 4-(6-chloro-3-pyridine)-1-piperazinecarboxylate mainly includes two steps:
1.4-(6-chloro-3-pyridine)-1-piperazinecarboxaldehyde is obtained by reacting 4-chloro-1-piperazinecarboxaldehyde with 6-chloro-3-pyridinecarboxaldehyde.
2. The above product is reacted with tert-butanol acid to generate the final product 4-(6-chloro-3-pyridine)-1-piperazinecarboxylic acid 1,1-dimethyl ethyl ester.

Safety Information:
-1,1-Dimethylethyl 4-(6-Chloro-3-pyridyl)-1-piperazinecarboxylate May be irritating to eyes, respiratory system and skin, contact should therefore be avoided during operation.
-Wear appropriate personal protective equipment, such as lab gloves, protective goggles and face shields.
-Should be used in a well-ventilated area to avoid inhalation or ingestion.
-If there is any safety concern or accident, consult a doctor immediately and show the chemical label or provide a safety data sheet to the doctor.

Last Update：2024-04-09 20:49:11