635728-49-3
Darunavir Ethanolate
CAS: 635728-49-3
Molecular Formula: C29H43N3O8S
635728-49-3 - Names and Identifiers
635728-49-3 - Physico-chemical Properties
| Molecular Formula | C29H43N3O8S |
| Molar Mass | 593.74 |
| Melting Point | 98-100°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White |
| Storage Condition | Refrigerator |
| Use | Darunavir Ethanolate is a human immunodeficiency virus (HIV) protease inhibitor. |
| In vitro study | Darunavir shows potent activity against HIV strains that are resistant to other available protease inhibitors. In L- MDR1 cells, Darunavir(121 mM) inhibited P-glycoprotein-mediated efflux of calcein acetoxymethyl ester. Darunavir is a protein that inhibits phenylalanine sequences mimicking positions 167 and 168 of the GAG-POL polypeptide, binding to the active site of HIV protease, thereby inhibiting its activity. Darunavir inhibits infection and replication of HIV-1 variants at concentrations up to 5 μm. Darunavir showed strong antiretroviral activity against 19 recombinant clinical isolates carrying multiple protease mutations that showed resistance to the other five protien inhibitors. Darunavir inhibited 75% of the tested PI-resistant viruses with EC50 up to 10 nM. |
| In vivo study | Darunavir is effective against wild-type and PI-resistant HIV, and has an oral bioavailability of 37%. It needs to be combined with ritonavir, which increases the bioavailability to 82%. |
635728-49-3 - Risk and Safety
| HS Code | 29334900 |
635728-49-3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.684 ml | 8.421 ml | 16.843 ml |
| 5 mM | 0.337 ml | 1.684 ml | 3.369 ml |
| 10 mM | 0.168 ml | 0.842 ml | 1.684 ml |
| 5 mM | 0.034 ml | 0.168 ml | 0.337 ml |
Last Update：2024-01-02 23:10:35
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