654055-01-3
4H-1-Benzopyran-4-one,2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-, hydrate (1:?)
CAS: 654055-01-3
Molecular Formula: C15H12O8
654055-01-3 - Names and Identifiers
| Name | 4H-1-Benzopyran-4-one,2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-, hydrate (1:?) |
| Synonyms | MORIN R. G. Morin hydrate Natural yellow 8 2′-Hydroxypelargidenolon MORIN FLUKA, FOR MICROSCOPY Morin hydrate,2′,3,4′,5,7-Pentahydroxyflavone 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one dihydrate 2μ,3,4μ,5,7-Pentahydroxyflavone dihydrate, 2μ,3,4μ,5,7-Pentahydroxyflavone |
| CAS | 654055-01-3 |
| EINECS | 684-856-6 |
654055-01-3 - Physico-chemical Properties
| Molecular Formula | C15H12O8 |
| Molar Mass | 320.25098 |
| Density | 1.799 g/cm3 |
| Melting Point | 299-300°C (dec.)(lit.) |
| Boling Point | 645.5 °C at 760 mmHg |
| Flash Point | 249.3 °C |
| Solubility | methanol: soluble50mg/mL |
| Appearance | powder |
| Color | yellow |
| Merck | 14,6269 |
| BRN | 327474 |
| Storage Condition | room temp |
| MDL | MFCD00217054 |
| Use | Fluorescent indicator, a reagent for fluorescence determination of several metals, such as Al, Be, Zn, Ga, In, SC. |
654055-01-3 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| RTECS | LK8749000 |
| HS Code | 29329990 |
| Hazard Class | 9 |
| Packing Group | III |
654055-01-3 - Introduction
Insoluble in water, slightly soluble in boiling water, soluble in organic solvents.
Last Update：2022-10-16 17:27:44
654055-01-3 - Reference Information
| overview | morin, also known as mulberry, a natural dye, is a light yellow pigment extracted from the bark of mulberry plants such as yellow mulberry tree and mulberry orange tree and many Chinese herbal medicines. The chemical name is 3,5,7,2 ', 4'-pentahydroxyflavone, which is a progesterone compound. The oxygen-containing heterocyclic ring connects two aromatic rings. The appearance of this product is usually yellow or gray-yellow needle-like crystals. It tastes bitter. Molecular weight 302.23. Melting point 285~290 ℃ (decomposition). Soluble in alcohol, acetone, slightly soluble in water, ether, acetic acid, ethyl acetate. It is strongly yellow when dissolved in alkali, and turns brown when exposed to air. There is light blue green fluorescence in concentrated sulfuric acid. Mainly used for dyeing wool, with different mordant can be yellow or green olive color, also used to make the lake, can also be used as a commonly used color developer in chemical analysis, generally used to detect trace amounts of iron, zinc, cobalt, etc. Morin can inhibit enzyme activity, has the effects of antioxidant, anti-pain, antibacterial, anti-inflammatory, anti-atherosclerosis, lowering blood sugar and anti-stress. Fig. 1 shows the structural formula of morin |
| pharmacological action | 1. antibacterial effect: morin has strong antibacterial effect on staphylococcus aureus, dysentery bacillus and typhoid bacillus. 2. Antiviral effect: morin 50ug/ml has anti-herpes virus effect and 2000ug/g has anti-potato virus effect. 3. Anti-cancer effect: Morin has a photosensitive killing effect on ascites-type liver cancer cells, inhibits the DNA synthesis of ascites-type liver cancer cells, and the inhibitory effect is strengthened with the increase of concentration and the extension of light exposure time. Under the condition of avoiding light, morin also has the ability to kill cancer cells. Morin has a permanent effect on the killing of ascites hepatoma cells, and the production of photosensitization is not related to O2 and O, but closely related to OH and H2O2. 4. Antispasmodic effect: Morin can inhibit cholinesterase and show antispasmodic effect. 5. Other effects: Morin has an inhibitory effect on the oxidative modification of low-density lipoprotein. Morin has obvious mutagenic effect on Salmonella typhimurium. Morin can inhibit aldose reductase, rats with 10-4g molecular concentration solution, inhibit aldose reductase 100%. In addition, morin has a diuretic effect. 25mg/kg has diuretic effect on rabbits. |
| Use | It can be used for antiviral infection, treating headache, stomach disease, chronic inflammation and coronary heart disease. Recently, it is also slowly used to treat cancer. It can destroy or inhibit the morphology and proliferation of cell lines such as liver cancer and esophageal squamous cell carcinoma, and can improve the respiratory control rate of cancer cells and lysosomal enzyme activity, interfering with the division of cancer cells and inhibiting their DNA synthesis. It has no inhibitory effect on bone marrow cells and can increase white blood cells. It is clinically used for liver cancer, esophageal cancer, gastric and cardiac cancer, and leukopenia. It can also be used as preoperative medication or combined chemotherapy. Combined with other chemotherapy drugs can improve the efficacy and reduce side effects. It is also effective for hepatitis B. The overview, pharmacological effects, uses, and metabolism of mulin are edited by Bao Quan. (2016-01-24) |
| mulin metabolism | mulin metabolism in vivo is mainly the hydrolysis reaction in the small intestine. ② Binding reaction in the small intestine: There are metabolic enzymes such as glucuronidase, sulfation enzyme and methylase in the epithelial cells of the intestinal wall. (iii) Hydrolytic metabolism in the large intestine: degradation of the split ring in the large intestine. ④Metabolism of flavonoids in the liver: The liver can convert drugs that enter the body into metabolites and finally excrete them from the body, which has a biotransformation effect. |
| color index | 75660 |
Last Update：2024-04-09 01:59:59
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View History
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