66656-92-6
Esculentoside H
CAS: 66656-92-6
Molecular Formula: C48H76O21
66656-92-6 - Names and Identifiers
66656-92-6 - Physico-chemical Properties
| Molecular Formula | C48H76O21 |
| Molar Mass | 989.1 |
| Density | 1.48±0.1 g/cm3(Predicted) |
| Melting Point | 218-220°C |
| Boling Point | 1042.8±65.0 °C(Predicted) |
| Specific Rotation(α) | +38.3 (c, 0.93 in EtOH) |
| Solubility | Soluble in methanol, butanol, water |
| Appearance | Powder |
| pKa | 12.52±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD29049459 |
66656-92-6 - Reference Information
| Overview | "Flora of China" records that Phytolacca PhytolaccaL. There are 35 species of plants in the world, of which there are 4 species in China, namely pokeweed PhytolaccaacinosaRoxb. P.americanaL., Duorui Pokeweed P.polyandraBatal. As well as P.ajaponicaMakino of Japan; and among them, the 2010 edition of the Chinese Pharmacopoeia included as medicinal use are Pokeweed and Pokeweed. As a traditional Chinese medicine, Shanglu has the effects of removing swelling by water, relieving stool, detoxifying and dispelling knots; it is mainly used to treat edema, fullness of stool, and external treatment of carbuncle, swelling and sore poison. Existing studies have found that the characteristic chemical components of Pokeweed are triterpene saponins, and their significant physiological activities have become a research hotspot. Modern pharmacological experiments have found that Pokeweed has significant diuretic, antibacterial, antiviral, anti-inflammatory, and anti-tumor activities; clinical use of Pokeweed to treat hepatitis B, psoriasis, leucorrhea, thrombocytopenic purpura and breast hyperplasia And other clinical difficult diseases. However, Pokeweed is a toxic traditional Chinese medicine, because of its toxicity, clinical use is greatly restricted. The types of compounds isolated from Phytolacca pokea include triterpene saponins, flavonoids, phenolic acids, sterols and polysaccharides, among which triterpene saponins and triterpene saponins have been studied in depth. |
| preparation method | a preparation method of pokeweed saponin, which is beneficial to large-scale production operations and has high product purity. The following technical scheme is adopted: the root coarse powder of Phytolacca acinatus is taken and added into a CO2 supercritical extractor, n-butanol is used as entrainment agent, the entrainment agent accounts for 24% of the total extraction solvent by volume, the extraction pressure is 20 40MPa, the temperature is 40 60 ℃, the CO2 flow rate is 1 3ml/g crude drug min, the extraction time is 80 150min, the extract is obtained, the extract is added to the macroporous adsorption resin column for adsorption, and the ethanol elution is 60 80%, collect 38 times the volume of the column eluent, recover the solvent under reduced pressure and dry it, add it to a silica gel chromatography column, and elute it with a mixed solvent of methanol and chloroform. The ratio of methanol to chloroform in the mixed solvent is 1:1. The eluent is collected according to the column fraction, and 37 parts of the column volume of the eluent are combined, concentrated, added with acetone for crystallization, separated, washed, and dried to obtain poolusside. |
| biological activity | Esculentoside H (EsH) is a water-soluble saponin isolated and purified from the root extract of perennial plant Phytolacca esculent. Esculentoside H (EH) has anti-tumor activity, and its mechanism is related to TNF release ability. Esculentoside H (EsH) inhibits the migration of colon cancer cells by blocking the expression of matrix metalloproteinase-9 (MMP-9) mediated by JNK1/2 and NF-κB signals. |
Last Update：2024-04-09 18:58:34
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