67139-79-1
4,6-dichloro-1H-pyrrolo[3,2-c]pyridine
CAS: 67139-79-1
Molecular Formula: C7H4Cl2N2
67139-79-1 - Names and Identifiers
| Name | 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine |
| Synonyms | Nsc293337 6-dichloro-1H-pyrrolo[3 4,6-Dichloro-5-azaindole 4,6-Dichloropyrrolo[3,2-c]pyridine 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine 4,6-Dichloro-1H-pyrrolo[3,2-c]pyridine 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE 1H-pyrrolo[3,2-c]pyridine, 4,6-dichloro- 1H-Pyrrolo[3,2-c]pyridine, 4,6-dichloro- 4,6-dichloro-1H-pyrrolo-[3,2-C]-pyridine |
| CAS | 67139-79-1 |
| EINECS | 200-258-5 |
| InChI | InChI=1/C7H4Cl2N2/c8-6-3-5-4(1-2-10-5)7(9)11-6/h1-3,10H |
67139-79-1 - Physico-chemical Properties
| Molecular Formula | C7H4Cl2N2 |
| Molar Mass | 187.03 |
| Density | 1.571±0.06 g/cm3(Predicted) |
| Melting Point | 258 °C(Solv: ethyl acetate (141-78-6)) |
| Boling Point | 371.6±37.0 °C(Predicted) |
| Flash Point | 210.2°C |
| Vapor Presure | 2.19E-05mmHg at 25°C |
| pKa | 13.40±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.708 |
67139-79-1 - Reference Information
| Introduction | 4, 6-dichloro-1h-pyrrolo [3,2-C pyridine is an organic intermediate, it can be obtained by using 2, 6-dichloro-4-nitro-pyridine as a raw material and cyclization. It has been reported in the literature to be useful in the preparation of influenza Virus replication inhibitors. |
| preparation | 2, 6-dichloro-4-nitro-pyridine (11g, 57mmol) dissolve in anhydrous tetrahydrofuran (300 mL) , cool to -78°C, and use bromine (vinyl) magnesium (1 M in THF, 200 mL, 200 mmol). The reaction was allowed to react at this temperature for 1 hour and then warmed to -20 °c. The reaction mixture was then quenched with 200ml of NH4Cl aqueous solution and the resulting mixture was partitioned in ethyl acetate. The aqueous layer was extracted three times with 200ml of ethyl acetate and the combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo. Purification by Combi flash chromatography using a 100% G column and gradient cyclohexane: 0-10% ethyl acetate, followed by a 40g column and a gradient dichloromethane: 0-ethyl acetate to give 4, 6-dichloro-1h-pyrrolo [3,2-C pyridine. |
Last Update：2024-04-10 22:29:15
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