6753-98-6
Alpha-Humulene
CAS: 6753-98-6
Molecular Formula: C15H24
6753-98-6 - Names and Identifiers
6753-98-6 - Physico-chemical Properties
| Molecular Formula | C15H24 |
| Molar Mass | 204.35 |
| Density | 0.889 g/mL at 20 °C(lit.) |
| Melting Point | <25 °C |
| Boling Point | 166-168 °C(lit.) |
| Flash Point | 90°C |
| Solubility | Insuluble (2.2E-6 g/L) (25 °C) |
| Appearance | neat |
| Color | Colourless |
| Merck | 14,4753 |
| BRN | 3240075 |
| Storage Condition | 2-8°C |
| Stability | Light Sensitive |
| Sensitive | Sensitive to air |
| Refractive Index | n20/D 1.503(lit.) |
| MDL | MFCD00042689 |
| Physical and Chemical Properties | Bioactive α-Humulene is a major component of Tanacetum vulgare L. essential oil and has anti-inflammatory effect (IC50=15±2 μg/mL). α-Humulene inhibits COX-2 and iNOS expression. |
| Use | Use ALPHA-Lvcene is one of the components in the essential oil extracted from flowering plant hops cones. The content of ALPHA-Lvcene in different plants is different. ALPHA-Lvcene and its reaction products make beer produce unique aroma during beer brewing. Existing studies suggest that the pharmacological studies of ALPHA-Lvcene have found that it has anti-inflammatory effects and can effectively prevent viruses that cause respiratory diseases such as colds and pneumonia from invading the human body. There have been no reports of relieving itching. |
6753-98-6 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | NA 1993 / PGIII |
| WGK Germany | 3 |
| RTECS | GZ4817500 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29021990 |
6753-98-6 - Upstream Downstream Industry
| Raw Materials | Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R,4E,9R)- BETA-CARYOPHYLLENE |
| Downstream Products | Caryophyllenolexcloveleafoil |
6753-98-6 - Reference
| Reference Show more | 1. Chen Jie, Chen CE, Liu ligan, Dai Bojian, Jin Xiaozhuang, Tang Jinlei, Deng Jiangnan. Effect of α-elicilene on improving schizophrenia by regulating NRG1/ErbB4 signaling pathway [J]. Chinese herbal medicine, 2019,50(23):5790-5794. 2. Li Xiaoqi, fan Yanhao, Chen Yang, et al. Simultaneous determination of four components in Patchouli by one-Test multi-evaluation method [J]. Chinese patent medicine 2019(8). 3. Hong zonchao, Wu and Zhen, Yang Yanfang, et al. Qualitative and Quantitative Analysis of volatile oil from Curcuma longa Longa based on GC-MS and GC [J]. Central South Pharmaceutical Journal, 2019, 17(03):112-120. |
6753-98-6 - Uses and synthesis methods
Introduction
ALPHA-Lvcene is an isomer of Lvcene, which is found in the essential oil of Humulus hops (Humulus lupulus). Its properties are colorless to slightly oily liquid, with light clove-like fragrance, boiling point 166~168 ℃, soluble in ether and ethanol, insoluble in water.
Target
COX-2
iNOS
in vitro studies
The cytotoxicity of α-Humulene against human lung carcinoma A549, colon adenocarcinoma DLD-1, skin fibroblasts WS1 cell lines is 28±1, 43±3, and 24±3 µg/mL, respetctively.
Last Update：2024-04-09 21:21:28
6753-98-6 - Nature
| EPA chemical information | 1,4,8-Cycloundecatriene, 2,6,6,9-tetramethyl-, (1E,4E,8E)- (6753-98-6) |
Last Update：2024-04-09 20:52:54
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